A comparative study between midazolam, ketamine and combination of both as a premedication in pediatric surgeries

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A comparative study between midazolam, ketamine and combination of both as a premedication in pediatric surgeries

Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 6, Issue 2

Abstract

Background: Midazolam andketamine are widely used oral pre anesthetic medication. This study was planned to compare midazolam and ketamine alone with combination of midazolam and ketamine as oral pre-anesthetic medication in children (2-10 Years) with respect to assess the levels of sedation, anxyolysis, behavior at parental separation and side effects. Methods: This prospective randomized study was conducted among childrenadmitted in various departments of Meenakshi Medical College Hospital and Research Institute, Kanchipuram during month of June 2014 to April2015. 150 patients between age 2-10 years, who belongs to ASA grade I and IIwere included. Patients with history of prematurity, developmental delay, increased intracranial pressure and increased intra ocular pressure were excluded. Children were randomized and divided into three groups and group A-midazolam (0.5mg/kg), group B -ketamine (6mg/kg) and group C - midazolam (0.5mg/kg) and ketamine (3mg/kg). The results were assessed in terms of levels of sedation, anxyolysis, behavior at parental separation and side effects. Results: Acceptable sedation score, anxyolysis score and behavior at parental separation score following midazolam use was 58%, 72% and 72%, respectively.Following ketamine use, 52% of children had acceptable sedation score, anxyolysis score and behavior at parental separation score. Combination of midazolam and ketamine use reported acceptable sedation score, nxyolysis score and parental separation score was reported as 68%, 82% and 82%, respectively. There was no significant difference in sedation in the 3 groups (p>0.05). Also, both anxiolysis and behavior at parental separation scores were significantly better in midazolam alone or in the combination group. Conclusion: Even though, the combination did not produce statistically better sedation, anxiolysis or behavior at parental separation than midazolam, the combination did produce distinctly better premedication characteristics than either midazolam or ketamine alone when given through oral route.

Authors and Affiliations

Mithun B, Anand B

Keywords

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EP ID EP360209
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