A Comparative Study between Propofol and Thiopentone as Induction Agents for Obstetric Anesthesia
Journal Title: Saudi Journal of Medicine - Year 2018, Vol 3, Issue 6
Abstract
Abstract:Intravenous induction agents Propofol and Thiopentone are commonly used in obstetric anesthesia. We in the present study tried to compare the effects of Propofol and thiopentone on hemodynamics, Heart rate in the pregnant ladies undergoing Cesarean sections. Methods A total of 60 patients were included in the study. They were randomly divided into two groups. Propofol group (n=30) and Thiopentone group (n=30). The dosage was calculated to body weight 5mg/Kg for thiopentone and 2.5mg/Kg for Propofol. The mean induction time in Propofol group was 20.95 seconds and Thiopentone group as 26.5 seconds. There was smooth induction in 86.67% of the patients of Propofol group and 13.33% had disturbed induction. In the Thiopentone group, 76.67% had smooth induction and 23.33% had disturbed induction. No induction failure was encountered in this study and all patients were unconscious after 45 seconds. The total duration of surgery in propofol group was 70 ± 20 minutes and in thiopentone group was 85 ± 27. The time to extubation in Propofol group was 8.5 ± 2.60 and Thiopentone group was 7.0 ± 3.56. The Arterial Blood gas analysis after surgery shows average values of PaO2 in Propofol group and 87.5 ± 2.1 and thiopentone group 88.6 ± 1.8 and PaCO2 in propofol group 38.6 ± 2.05 and thiopentone 38.4 ± 2.5 mmHg. The mean SBP at the baseline of Propofol group was 124.05 ± 10.5 mmHg,while for Thiopentone group it was 124.05 ± 10.5 mmHg. The mean DBP at the baseline in propofol group was 76.5 ± 10.2 and thiopentone group was 78.8 ± 6.8. The heart rates were 80.5 ± 7.8 beats/min and 83.5 ± 8.8 beats/min in propofol and thiopentone group. The mean changes at the time of induction in heart rate of propofol group were 18 beats/min and the mean change of heart in thiopentone group was 23 beats/min. The mean SBP change during induction in Propofol group was -2.8mmHg and DBP change was -2.0 mmHg. In thiopentone group SBP change was -2.55mmHg and DBP change was -1.3 mmHg. Conclusion: Propofol has rapid actions and does not have any adverse effects on the CVS. The amount of pain produced due to propofol was also lesser compared to the thiopentone group and the induction was smooth in propofol group compared to thiopentone group and overall outcomes of Propofol were better than the Thiopentone group. Therefore propofol appears to better induction agent than thiopentone for obstetric anesthesia. Keywords: Thiopentone, Propofol, Obstetric anesthesia.
Authors and Affiliations
BH Venkatareddy
Keywords
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