A Comparative Study between Semi-Quantitative Analysis in [F-18]FDG Brain PET/ CT Scan using Two Different Software Packages in the Diagnosis of Alzheimer’s Disease
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2021, Vol 65, Issue 1
Abstract
Objectives: To compare the results from semi-quantitative analysis of [F-18]FDG brain PET/CT scan obtained from two different software packages (CortexID and Q.brain). In addition, to evaluate the diagnostic performance of 3D-SSP Z-score map images obtained from 2 software packages in the diagnosis of Alzheimer’s disease as compared to gold standard. Methods: Retrospective study was done on pre-existing data of [F-18]FDG PET/ CT images acquired from 85 elderly Thai participants (21 cognitively normal elderly subjects, 32 patients with mild cognitive impairment and 32 patients with Alzheimer’s disease). Semi-quantitative analysis of all PET images was performed using 2 software packages and Z-score results were compared. The diagnostic performance in Alzheimer’s disease was also assessed using gold standard. t-test was applied for statistical analysis and p value <0.05 was considered as statistically significant. Results: There werestatistically significant differencein Z-scoreresults at bilateral medial frontal and bilateral occipital association regions using all normalized regions and left posterior cingulate using global cortex and cerebellar normalization. The sensitivity, specificity, accuracy, PPV, NPV, LR- CortexID were 79.17%, 100%, 89.13%, 100%, 81.48% and 0.21, respectively for AD diagnosis, which were better than those of Q. brain. Conclusion: The Z-score results from 2 different software packages in [F-18]FDG brain PET can be significantly different in some regions, which should be careful for interpretation. Pons normalization may reduce this difference. In this pilot study, CortexID software package shows better performance in differentiating AD from normal elderly.
Authors and Affiliations
Maneerat Jubjitt, Tanyaluck Thientunyakit, Chakmeedaj Sethanandha
Keywords
Related Articles
- EP ID EP723300
- DOI http://dx.doi.org/10.14456/vmj.2021.2
- Views 22
- Downloads 0
Clinical Characteristics and Outcomes of Acute Myeloid Leukemia in Vajira Hospital-a 9-year Single Center Retrospective Study
Objective: To collect demographic data, management patterns and outcomes of acute myeloid leukemia (AML) patients in a tertiary hospital. Methods: We collected data of newly diagnosed AML patients from 2008 to 2016, inc...
A comparison of laparoscopic versus open appendectomy for overweight patients in Bangkok Metropolitan Administration General Hospital: a retrospective study
Objectives: To compare the result of appendicitis treatment between laparoscopic surgery (LA) and open surgery (OA) in overweight patient. In term of hospital length of stay (LOS), intraoperative time, time to resume die...
Driving Pressure and Lung Injury in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome
Background: Driving pressure is associated with mortality in patients with acute respiratory distress syndrome (ARDS). However, whether driving pressure is associated with outcomes in mechanically ventilated patients wit...
Car Seat Knowledge and Car Seat Use among Parents of Preschool Children in Bangkok, Thailand
Background: Road traffic accident is one of the leading causes of death in children. Appropriate car seat use can reduce the severity of injuries. Objective: The aims of this study were to collect information on car sea...
Risk Factors of Birth Injury in Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Objective: To determine the incidence and associated risk factors of birth injury among neonate who were born at Faculty of Medicine Vajira Hospital, Navamindradhiraj University from 2014-2016. Study design: Case contr...