A Comparative Study Efficacy of Ondansetron versus Granisetron to Prevent Perioperative Nausea and Vomiting among Patients Undergoing Gynaecological Surgery Under Spinal Anaesthesia in a Tertiary Care Hospital of Western India
Journal Title: National Journal of Medical Research - Year 2018, Vol 8, Issue 2
Abstract
"Background: In India Post-Operative Nausea and vomiting (PONV) remains a persistent and distressing problem in spite of many advances on perioperative care and anti-emetic medicines. A randomized double blind study was conducted to compare efficacy of Ondansetron versus Granisetron among patients undergoing gynaecological surgery under the spinal anaesthesia Objective: To compare Ondansetron and Granisetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Material and methods: Total 60 consecutive patients, age between 18-58 years, ASA grade I and II undergoing gynaecological surgery under the spinal anaesthesia were randomized into two groups of 30 each. One group received I.V. Ondansetron 4.0 mg and the second received I.V. Granisetron 2.0 mg 5 minutes before induction of anaesthesia. For the first 24 hours postoperatively all episodes of nausea and vomiting were recorded. The observations were tabulated and analysed. Results: In this study found that during early postoperative period (0-3 hrs) there was no statistically significant difference in the study groups. Statistically significant difference was found in the study groups in the late postoperative period (3-24 hrs). Conclusion: In the early postoperative period both Ondansetron and Granisetron are equally effective in preventing postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Granisetron is better than Ondansetron in the late postoperative period of upto 24 hrs.
Authors and Affiliations
Purvi Mehta, Archana Vaghela, Bhavna Soni, Pragna Vachhrajani
Keywords
Related Articles
- EP ID EP618374
- DOI -
- Views 107
- Downloads 0
Regional Variation of Morphometric Measurements of Proximal End of Femur in Coastal Andhra Pradesh and its Clinical Implication to Improve Surgical Outcome
Introduction: The neck of femur is an important modification in human being. The neck-shaft angle and different parameters of neck are clinically important to diagnose pathological conditions of the hip joint and also he...
Venlafaxine as an Augmentation of Electro- Convulsive Therapy in Treatment Resistant Depression- A Case Report
Treatment of challenging cases of Depression with or without psychotic features often needs use of Electro-convulsive Therapy at some stage. The purpose of this case report is to demonstrate the effectiveness of augmenta...
Magnitude and Determinants of Noncompliance for Screening and Management of Diabetic Retinopathy
"Introduction: Strategies to reduce visual disabilities due to diabetic retinopathy (DR) include early detection and prompt management. Patient compliance is a crucial a factor to achieve this goal. The aim of the study...
Morphometric Dimensions of Human Ear Ossicles of Males
Introduction: The otologic surgeons need to be fully conversant with the anatomical details of middle ear and its bones so as to perform microsurgical maneuvers successfully. In India, data on normal anatomical parameter...
The Role of Tranexamic Acid topical Administration for Primary Hemiarthroplasty
Introduction: Tranexamic acis is an inhibitor of fibrinolysis & plasminogen activator which inhibits blood loss during surgery. Intravenous route administration can cause thromboembolic complications. Hence we decided to...