A Comparative Study of 2% Lignocaine vs 50% Magnesium Sulphate for Attenuation of Stress Responses to Laryngoscopy and Endotracheal Intubation
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Laryngoscopy and endotracheal intubation are essential parts of induction of general anaesthesia. Present study was undertaken to evaluate and compare the efficacy of lignocaine and magnesium sulphate for attenuating the stress responses to laryngoscopy and endotracheal intubation. Material and Methods: The study enrolling 100 patients of either sex, age between 18-50 years, ASA grade I and II were randomly allocated in two equal groups to receive either 2% lignocaine (1.5 mg/kg) or 50% magnesium sulphate (40 mg/kg) via intravenous route. Anesthesia was induced with intravenous thiopentone sodium 5 mg/kg followed by injection succinylcholine 1.5 mg/ kg. The smooth gentle laryngoscopy and tracheal intubation was performed within 30 second. The haemodynamic parameters like HR, SBP, DBP, MAP and rate pressure product at various time intervals up to 5 minutes post-intubation were recorded and efficacy of both drugs to reduce haemodynamic responses was compared with Z test. Results: In lignocaine group, there was significant rise in heart rate, blood pressure and rate pressure product in post intubation period which does not came to baseline value at 5 min after intubation. Rate pressure product crossed the angina limit of 12000 in more than 50% patients. In MgSO4 group, heart rate, blood pressure and rate pressure product were increase significantly only at 1 min after intubation and which came to baseline up to 5 min after intubation. Rate pressure product did not cross the angina limit of 12000 significantly. There were no any complications observed in our study. Conclusion: We concluded that magnesium sulphate is better alternative to lignocaine for attenuation of stress responses of laryngoscopy and intubation.
Authors and Affiliations
Sachin Padmawar, Manish Patil
Keywords
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