A COMPARATIVE STUDY OF ANTI-CATARACT ACTIVITY OF TRIPHALA AND ITS CONSTITUENTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Cataract is referred as clouding of lens of the eyes, a major cause of blindness all over the world. There is a wide spread belief that the herbal medicines have fewer side effects compared to allopathic medicines. Hence the present study comprises the comparison of anti-cataract activity of Triphala, an herbal formulation and its constituents Terminalia chebula, Terminalia bellerica and Emblica officinalis in-vitro. Goat lenses were incubated in artificial aqueous humor containing 55mM glucose with Triphala formulation and its individual constituents separately at different dose levels (400µg/ml, 800µg/ml and 1200µg/ml) at room temperature for 72h. Evaluation was done by using biochemical parameters like superoxide dismutase (SOD), malondialdehyde (MDA), total protein, electrolytes (Na+, K+) and Na+/ K+- ATPase activity. The glucose induced opacification of goat lens was also studied as a part of visual evaluation. Present study reveals that lenses treated with Triphala and its individual constituents shows significant decrease in, loss of transparency in the lens, MDA and Na+ levels. There was also significant increase in SOD, total protein and Na +/K+- ATPase activity, thereby Triphala and its individual constituents prevents the formation and progress of cataract induced by glucose. The Triphala formulation at higher dose level (1200 μg/ml) shows much more significant preventive effect on cataract formation than its individual components. From the present we conclude that Triphala formulation effectively shows anti-cataract activity comparatively to its individual components. Hence the finding of the present study provides the evidence of beneficial effect of Triphala in the patients suffering from cataract.
Authors and Affiliations
Chakrakodi Shastry , Bharath Raj , Aswathanarayana BJ
Keywords
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