A COMPARATIVE STUDY OF ANTI INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF FENUGREEK (TRIGONELLA FOENUM GRAECUM) AND CARAWAY (CARUM CARVI) AQUEOUS AND OIL SEED EXTRACTS IN EXPERIMENTAL MODEL OF ULCERATIVE COLITIS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 3
Abstract
Ulcerative colitis is a chronic inflammatory bowel disorder that increase the risk of colon cancer. The usage of natural antioxidants exhibit great interest as a means to avoid oxidative damage. This study evaluated the effect of fenugreek and caraway either in form of aqueous or oil seeds extracts on experimental model of ulcerative colitis in rats. Colitis was induced using of 4% acetic acid solution. Groups were: G1: healthy control group, G2: ulcerative colitis group, G (3, 4) : ulcerative colitis supplemented with fenugreek aqueous and oil extracts, respectively, G (5, 6) : ulcerative colitis supplemented with caraway aqueous and oil extracts, respectively. Colon samples were assayed for oxidative stress and inflammatory biomarkers along with colon histology and DNA fragmentation. Results showed that treatment with fenugreek and caraway either in form of aqueous extract or seed oil extracts protect against ulcerative colitis effects as shown by improvement in antioxidant enzymes level and inflammatory biomarkers, histological and genetical evaluation. These findings indicated that fenugreek and caraway aqueous and oils extracts have defensive effects against acetic acid-induced ulcerative colitis which might due to their anti-inflammatory, antiulcerative and antioxidant properties. Therefore, they can possibly used for successful treatment of ulcerative colitis.
Authors and Affiliations
Mai Elsayed
Keywords
Related Articles
- EP ID EP671944
- DOI -
- Views 139
- Downloads 0
PRESCRIBING TRENDS OF ANTI-ULCERANT DRUGS BY GENERIC NAMES IN DHAKA CITY OF BANGLADESH
This study aimed to identify the prescribing preference of anti-ulcerant drugs among the physicians and dentists of Dhaka City, Bangladesh by generic names. A questionnaire-based field survey was conducted on the physici...
ARANEISM BY Kukulcania cf tractans IN MATURE ADULT MALE FROM MEXICO: A CASE REPORT
In this paper the case of an adult man with spider bite of Kukulcania cf. tractans ("Kukulcanism") (family Filistatidae) presented in Mexico is described. The bite was caused in distal third of right leg, with developmen...
COMPARATIVE ANALYSIS BETWEEN INFECTIOUS AND NONINFECTIOUS IRRITABLE BOWEL SYNDROME
Objective: To compare the post-infectious irritable bowel syndrome (PI-IBS) and none post-infectious irritable bowel syndrome (NPI-IBS) clinically and experimentally. Methods: From May 2015 to January 2017, eighty-nine p...
TESTING OF AMOXICILLIN LEVELS IN RESISTANCE CASES IN AN EFFORT TO MONITOR ANTIBIOTIC DRUG QUALITY AT THE TASIKMALAYA CITY HEALTH CENTER, INDONESIA
Objective: Acute respiratory infection (ARIs) is an acute inflammation of the upper and lower respiratory tract caused by microorganisms, bacteria, viruses, and infectious rickets. Evaluation of the quality of antibiotic...
EVALUATION OF SHOTHAHARA MAHAKASHAYA OF CHARAK SAMHITA: A LITERARY REVIEW
Shothahara mahakashaya denotes group of ten medicines, which act on Shotha roga. Shotha roga can be correlated with the term edema/Swelling of modern medicine. Shothahara Mahakashaya is the 38th gana of the 50 mahakashay...