A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2011, Vol 24, Issue 4
Abstract
The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.
Authors and Affiliations
Nawazish Syed, Shamas Arshad, Amir Syed, Maqsood Ahmad, Farrakh Khan, Bashir Ahmad
Keywords
Related Articles
- EP ID EP160742
- DOI -
- Views 100
- Downloads 0
Acute toxicity and antispasmodic activities of Achillea wilhelmsii C. Koch
Abstract: Since Achillea wilhelmsii is used as antispasmodic in traditional medicine, we conducted our current work to investigate its rationale on scientific grounds. Acute toxicity studies of crude methanol extra...
Formulation and optimization of gastric floating drug delivery system using Central composite design and its biopharmaceutical evaluation
The present work investigates the formulation and biopharmaceutical estimation of gastric floating drug delivery system (GFDDS) of propranolol HCl using semi-synthetic polymer carboxymethyl ethyl cellulose (CMEC) a...
Phytochemical analysis, antimicrobial, antioxidant activities and total phenols of Ferulago carduchorum in two vegetative stages (flower and fruit)
Ferulago carduchorum (Apiaceae family) is an endemic plant of Iran. The crude extract and four fractions of aerial parts of F. carduchorum in two vegetative stages (flower and fruit) were studied for their total ph...
Synthesis, antimicrobial and antifungal possessions of tramadol esters: In vitro studies
Tramadol esters were prepared by refluxing equimolar concentration of tramadol with leucine and asparagine separately with methanol, sulphuric acid and phthalic anhydride for 10 hours and temperature was maintained...
Central nervous system (CNS) toxicity caused by metal poisoning: Brain as a target organ
People relate the neural disorders with either inheritance or psychological violence but there might be some other reasons responsible for the ailment of people that do not have such a background. The present study...