A COMPARATIVE STUDY OF BUPIVACAINE AND FENTANYL - BUPIVACAINE IN LOWER ABDOMINAL SURGERY UNDER EPIDURAL ANESTHESIA
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 6, Issue 1
Abstract
Background: Fentanyl is an opioid general anaesthetic acting through the opioid receptors. Combination with local anaesthetics increases the onset and duration of analgesia. The present study compared the efficacy profile of epidurally administered bupivacaine alone and fentanyl combined with bupivacaine. Materials and Methods: A total of 30 adult patients of either sex aged 20-50 years, undergoing lower abdominal elective surgery under epidural anesthesia were included in the present study. Patients were randomly divided into two groups of 15 each. Bupivacaine (0.5%) 20 ml was administered for both the groups epidurally and 100μg fentanyl was given to the second group. The onset and duration of sensory analgesia were observed and compared. Postoperative visual analgesic scale scores were also noted and compared. Data was analyzed using unpaired “t†test. Results: The demographic profile of patients was comparable in two groups. Onset of analgesia was earliest in second group compared to the first group. The duration of analgesia was also significantly prolonged in second group. There was no significance difference in the VAS scores between two groups throughout the study period. Conclusions: Fentanyl and bupivacaine group has early onset of analgesia as well as produced prolonged duration. Hence, the combination of fentanyl and bupivacaine may useful in feature clinical settings.
Authors and Affiliations
Mohan K| Department of Anaesthesia, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India, Mohana Rupa L| Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India
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