A Comparative Study of Clinical Outcome of Use of Topical 2% Sertaconazole Versus 1% Terbinafineas Monotherapy in the Treatment of Tinea Corporis
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 11
Abstract
Tinea corporis, a superficial fungal infection caused by dermatophytes is highly prevalent in India. This condition primarily affects the limbs and the trunk and can severely impair the quality of life of the patient. Aim: To compare the outcome of use of Terbinafine and Sertaconazole as monotherapy in the treatment of tinea corporis. Materials and Methods: 58 patients were enrolled in this single blind parallel therapeutic trial.The patients were allocated to each arm of the study by stratified random sampling. Group A received treatment with Sertaconazole nitrate 2 % cream while group B received treatment with terbinafine hydrochloride 1% cream twice daily. The patients were reviewed weekly for 4 weeks and followed up for 2 weeks after completion of treatment. The primary outcome measures were percentage of patients showing clinical and mycological cure while mean improvement in clinical score was a secondary outcome measure. Results: 50 patients out of 58 completed the study,25 in each arm. Between the two arms, more percentage of patients in the Sertaconazole arm showed mycological clearance at weeks 2 and 3(48 and 76%) compared to Terbinafine (28 & 68%) respectively. A significantly larger number of patients in the Sertaconazole arm showed complete or near complete improvement in clinical scores(84%) at week 3 compared to those in the Terbinafine arm (68%). The mean improvement in clinical scores was significantly higher for the patients in the Sertaconazole arm at weeks 2 and 3. Conclusion: Sertaconazole showed faster mycological clearance and could achieve better percentage of clinical cure in a shorter duration when compared to terbinafine.
Authors and Affiliations
Manogna Vellala
Keywords
Related Articles
- EP ID EP214829
- DOI -
- Views 75
- Downloads 0
Haemodynamic changes with lower dose of Hyperbaric Bupivacaine with Dexmeditomedine and Conventional dose of Hyperbaric Bupivacaine for Subarachnoid Block in Lower Limb Surgeries (Orthopaedic Cases)
Background and Aims: It is universally agreed that the anaesthesia of choice for lower limb surgeries is a subarachnoid block and a sensory level of T – 10 is recommended to provide excellent anaesthesia for the patient....
A Study on Knowledge and Attitude of Anganwadi Workers Regarding Infant and Young Child Feeding Practices in a Rural Area
Objectives: (1) To study Knowledge & Attitude of Anganwadi Workers (AWWs) regarding Infant and young child feeding (IYCF) practices. (2) To assess Knowledge of AWWs with respect to Infant &Young Child feeding practices i...
Ultrasonographic Evaluation of Acute Abdomen In Children
Acute abdomen is a medical emergency, in which there is sudden and severe pain in abdomen of recent onset with accompanying signs and symptoms that focus on an abdominal involvement. It can represent a wide spectrum of c...
Breast Feeding Knowledge Attitude and Practices amongst Mothers of Rural and Tribal Region
Introduction: The practice of breast feeding is popular since ancient times. Though some mothers understand the importance of breast feeding, but others are less knowledgeable on the benefits of breastfeeding and complem...
A study on safety and efficacy of Deferasirox, an oral iron chelator in the treatment of transfusion haemosiderosis in children with β-Thalassemia Major in a tertiary care rural hospital
Background: β-Thalassemia major is a hereditary hemolytic anaemia (and the commonest transfusion dependent anaemia) which continues to be a major cause of morbidity and mortality in developing countries like India. Defer...