A Comparative Study of Dexmedetomidine HCL and Esmolol HCL for Attenuating Pressor Response to Laryngoscopy and Oral Endotracheal Intubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 9
Abstract
Introduction: Laryngoscopy and intubation increases sympathetic activity resulting in tachycardia and hypertension which may cause myocardial ischemia, cardiac arrhythmias and cerebrovascular hemorrhage. We compared the efficacy of intravenous esmolol and dexmedetomidine to attenuate the pressor response to laryngoscopy and intubation. Design: Randomised controlled trial. Method: Seventy-five patients of ASA I and ASA II undergoing general anesthesia with oral intubation for elective surgery were allocated into three groups.Group C: Control group. Group E: intravenous esmolol 2mg/kg three minutes before laryngoscopy. Group D: Intravenous dexmedetomidine 1g/kg in 100ml infusion over ten minutes before laryngoscopy. Heart rate, systolic, diastolic and mean arterial pressures were recorded before drug administration, after drug administration, after induction of standard anesthesia, immediately after intubation, every 2 minutes till 10 minutes. Incidence of bradycardia and hypotension were noted. Statistical Analysis used: IBM SPSS version. Results: Mean HR immediately after intubation for group C was (104.57±8.2) whereas it was (83±4.53, 92.6±4.70) for group D and group E with p value of (0.003,0.002) when compared to control group. While comparing group D and E, p value was 0.0001. MAP immediately after intubation for group C was (109±5.9) whereas it was (98±3.4, 100.2±5.2) for group D and E with p value (0.0001, 0.002) when compared to control group. While comparing group D and E, p value was 0.006. Conclusion: Dexmedetomidine and esmolol both attenuated the pressor response to laryngoscopy and intubation but it was better controlled with dexmedetomidine.
Authors and Affiliations
Patel Leena
Keywords
Related Articles
- EP ID EP539134
- DOI 10.21088/ijaa.2349.8471.5918.13
- Views 83
- Downloads 0
Comparative Study of Prevention of Hypothermia Using Preoperative as well as Intraoperative Forced Air Warming with Only Intraoperative Warming in Patients of Surgeries Under General Anaesthesia
Background: Peri-operative hypothermia is very common and associated with many complications. Hypotheremia is most evident in first two hours due to redistribution of heat after induction of general anaesthesia. The stud...
Evaluation of I-Gel and LMA-C Clinical Presentation in Anaesthetized Patients
Introduction: Igel and LMAC are most commonly used supraglottic air way devices to secure the airway during general anaesthesia our main objectives were to compare the ease of insertion, duration of insertion and numbe...
Evaluation of Vibration Sense and Motor Power Following Epidural Anaesthesia
Background: It is very important to see complete recovery from regional anaesthesia before ambulation and discharge of the patient. Bromage score or the Formal motor power test system are the conventional methods which h...
Tap the Potential of Tap Block: A Schematic Representation
ransversus abdominis plane (TAP) block is an abdominal or truncal field block. Its popularity has increased in the recent times, mainly because its widespread applicability in several abdominal surgeries and less inciden...
Haemodynamic Effects of LMA Fastrach versus Macintosh Laryngoscope While Intubation in Patients Undergoing Cabg
Coronary artery bypass grafting (CABG) surgery is still the predominant operative procedure for myocardial revascularization. The pressor response to intubation is a detrimental factor in these patients, where stable hem...