A Comparative Study of Dexmedetomidine Versus Esmolol To Attenuate The Haemodynamic Pressor Response To Laryngoscopy And Intubation
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Introduction: The cardiovascular responses during laryngoscopy and endotracheal intubation should be abolished to balance the myocardial oxygen supply and demand which is a key note in the safe conduct of anaesthesia. Attempts to reduce these untoward haemodynamic responses lead to the trial of various systemic as well as topical agents. This study was conducted to compare the efficacy of IV Dexmedetomidine and IV Esmolol to attenuate cardiovascular response during laryngoscopy and endotracheal intubation in normotensive patients. Objective: To compare the effectiveness of dexmedetomidine or esmolol in attenuating the hemodynamic responses during laryngoscopy and endotracheal intubation. Methods: Hundred adult ASA I and ASA II patients were included in the study who underwent elective surgical procedures. Patients were divided into two groups. Group D receiving Dexmedetomidine 1.0 µ/kg as slow IV infusion over 10 min and Group E receiving Esmolol 1.0 mg/kg as slow IV infusion over 10 min. Study drug was injected 3 min before induction of anesthesia. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were recorded baseline, after study drug infusion, immediately and 1, 3, 5, 7 and 10 min. after intubation. Results: Reading of heart rate, blood pressure and mean arterial pressure were compared with baseline and among each group. The rise in heart rate was minimal in dexmedetomidine group. Also the increase in systemic blood pressures and mean arterial pressure at the time of intubation and upto 10 mins. after intubation was minimal in dexmedetomidine group. Conclusion: Administration of 1µg/kg slow IV dose of dexmedetomidine before induction of general anaesthesia significantly attenuated heart rates, blood pressures when compared to 1mg/kg slow IV dose of esmolol.
Authors and Affiliations
Dr. Bhavani Gonapa, Dr. Swetha Munipalle
Keywords
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- EP ID EP582825
- DOI 10.9790/0853-1711114550
- Views 58
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