A comparative study of efficacy and safety of oral ketamine and oral midazolam as premedicant for paediatric cardiac catheterization
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 3
Abstract
Use of an effective sedative premedicant significantly minimizes the emotional trauma associated with perioperative anxiety and its sequelae Currently oral midazolam is the most commonly used premedicant in most of the countries followed by oral ketamineAims and Objectives To compare the efficacy and safety of oral ketamine and oral midazolam as premedicant for paediatric cardiac catheterizationMaterials and Methods This study was carried out in the tertiary care centre in sixty patients randomly assigned into two groups of thirty patients each to compare the efficacy of oral ketamine and oral midazolam pre medication as sedative for paediatric patients undergoing cardiac catheterization using various parametes and observation scale of response and Visual Analogue scale Data collected was analysed and the statistical significance of these intragroup and intergroup observations thus made was determined using either a Chi Square test or an Unpaired Ttest or Mann whitney testResults The demographic trends in all the groups were comparable The type of procedure performed were also comparable in both the groups The mean heart rate mean systolic and diastolic blood pressures mean arterial blood pressure were higher in the ketamine group than in the midazolam group Though there was fall in oxygen saturation in both the groups the ketamine group required oxygen supplementation more than midazolam group though it was statistically insignificantThe mean onset of sedation was earlier for midazolam than for ketamine Also the parental separation was smoother and calmer in patients who had oral midazolam than oral ketamineSimilarly while positioning the children for cath study also patients medicated with midazolam showed better response than those medicated with ketamine The response to local anaesthetic injection during femoral vessels cannulation also showed midazolam with better results The adverse effects such as secretions nystagmus nausea vomiting delirium were more common with ketamine The mean time spent in recovery was 5333 minutes with ketamine group and also parental satisfaction in terms of VAS score is better and favours midazolam than ketamineConclusions Oral midazolam is a better premedication of choice than ketamine for paediatric patients undergoing cardiac catheterizationKeywords Sedation Anxiety Procedure
Authors and Affiliations
Soma Ganesh Raja, Gowri Shankar Sarate
Keywords
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- EP ID EP476483
- DOI 10.18231/2394-4994.2018.0067
- Views 78
- Downloads 0
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