A COMPARATIVE STUDY OF EFFICACY OF CENTCHROMAN AND EVENING PRIMROSE OIL IN TREATMENT OF BENIGN BREAST DISEASE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 31
Abstract
BACKGROUND Fibroadenomas are the most common breast lumps in women younger than 30 yrs. of age and the most common solid tumours in breast of women of all ages with a peak incidence at around 20 yrs. of age. Hormonal therapy of fibroadenomas is the common mode of treatment and tamoxifen reduces volume of fibroadenomas by around 20%. Centchroman is a non-steroidal, selective anti-oestrogen and has the advantages of less frequent administration and is free from side effects of steroidal agents. It has an excellent safety profile even in lactating women. It is free from teratogenic, mutagenic or carcinogenic side effects. Centchroman elicits weak oestrogenic agonistic and potent antagonistic activities, but is devoid of progestational, androgenic and antiandrogenic properties. The aim of the study is to compare the efficacy of Centchroman and Evening Primrose oil in treating breast pain with or without nodularity in patients with fibrocystic disease and regression of smaller fibroadenomas (< 4 cm). MATERIALS AND METHODS This longitudinal study was conducted in Department of General Surgery and included female patients aged 16 - 35 yrs. presenting to outpatient department, suffering from benign breast disease. The study was conducted from June 2017 to May 2018 and included 140 patients, 82 in Centchroman group and 58 in EPO group. RESULTS Majority of the patients in Centhroman group (84%) responded excellently compared to EPO (Evening Primrose Oil) group (25%) with respect mastalgia. Nodularity decreased in 80% of patients in Centchroman arm and 26% in EPO arm. Complete response to treatment of fibroadenoma was noted in 40% of patients with Centchroman treatment, while only a dismal of 6% (1 patient) showed response to EPO treatment. CONCLUSION Most patients with benign breast disease present in the third decade of life. The most common symptom in patients with benign breast disease is mastalgia followed by tender nodularity of breasts. Centchroman is significantly better than Evening Primrose Oil (EPO) in causing regression of breast lumps in fibroadenomas, in causing relief from breast pain in benign breast disease and in regression of tender nodularity in patients of fibrocystic disease of the breast. Both Centchroman and EPO have excellent safety and side effect profile with no serious adverse effects reported in either of the treatment groups.
Authors and Affiliations
Sreeja Biswas Roy, Rasbihari Hembram
Keywords
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- EP ID EP541028
- DOI 10.14260/jemds/2018/791
- Views 74
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