A COMPARATIVE STUDY OF EFFICACY OF CLOTRIMAZOLE AND FLUCONAZOLE EAR DROPS IN OTOMYCOSIS
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2018, Vol 2, Issue 5
Abstract
Background: Otomycosis is a clinical term to describe fungal infection of the external auditory canal. Most common fungi implicated in this infection are Aspergillus and Candida. Treatment of choice for fungal otitis externa includes thorough debridement followed by topical application of antifungal agents. Objective: To evaluate and compare the efficacy of clotrimazole and fluconazole in empirical treatment and to appraise possible better outcome in otomycosis. Materials and methods: 300 patients with otomycosis were selected and divided into two groups. Patients in Group A were put on 1% Clotrimazole ear drops and those in Group B were put on 0.3% Fluconazole ear drops. All patients were reviewed weekly for 4 weeks for reduction in symptoms and signs. Results and interpretation: Baseline characteristics of the study participants are comparable and there was no significant difference between the groups. Pain was the main presenting feature in both the groups followed by itching and ear block. Symptoms lasted for 1- 10 days. Aspergillus Niger was most common fungus isolated, followed by Aspergillus flavus, Aspergillus fumigatus and Candida. Comparing the two groups, the effectiveness of fluconazole was found to be better than clotrimazole at the end of 2nd week, 3rd week and 4th week. Conclusion: In our study, we have observed that topical Fluconazole is more effective than Clotrimazole to treat otomycosis. Keywords: Otomycosis, Topical antifungals, Fluconazole, Clotrimazole, Fungal otitis externa
Authors and Affiliations
Dr. S. M. Kanade
Keywords
Related Articles
- EP ID EP547605
- DOI -
- Views 30
- Downloads 0
To study the role of x-ray in maxillofacial fractures diagnosis.
Background- Facial injury constitutes a frequent finding among emergency room patients. Methods- This study has been conducted in the Department of dental and radiology, on 30 patients with suspected maxillofacial fractu...
DIAGNOSTIC IMAGING OF DENTIGEROUS CYSTS
Background- Dentigerous cysts are the second most common odontogenic cysts after radicular cysts. Methods- DC cases of 30 patients who applied to our hospital .who had histopathological diagnosis were examined retrospect...
Morphometric assessment of microvessel density by CD105 and CD34 receptor
AIM: To evaluate and compare microvessel density morphometrically using endoglin (CD105) with CD34, a pan-endothelial marker in different histological grades of astrocytoma. Methods: In 61 cases of astrocytoma, the expre...
A Method for Malaria Parasites Detection Systems
Malaria disease is present in semi urban and non-urban areas especially in developing countries. It is always found that non-occurrence of the malaria disease in patients is more than occurrence of malaria disease in pat...
ROLE OF SONOGRAPHIC IMAGING AND SPERM COUNT IN MALE INFERTILITY
Male infertility is more importance with male factors which implicated as the cause to half of the infertile couples. Besides routine investigations ultra sonography of trans rectal and scrotal was performed to detect te...