A COMPARATIVE STUDY OF EFFICACY OF LOCAL INSULIN VERSUS TOPICAL PHENYTOIN IN DIABETIC FOOT ULCER
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 51
Abstract
BACKGROUND Diabetic foot ulcer is the common complication and it affects almost 15% of all diabetic patients. Majority of the ulcer can heal. Healing is better in neuropathic ulcer than neuroischaemic ulcer. In India, diabetic foot ulcer is common cause of nontraumatic amputation of limbs, which is preventable. MATERIALS AND METHODS It is an open labelled randomised prospective study conducted at Department of General Surgery, Konaseema Institute of Medical Sciences, Amalapuram. Total 90 patients divided randomly into three groups include this study as per exclusion and inclusion criteria. Group A were diabetic foot ulcer belongs to topical insulin dressing group. Group B belongs to topical phenytoin group and group C belongs to conventional wound care group. RESULTS In group A, size of the wound reduced from mean value 6.8 cm2 to 1.4 cm2 ; percentage change in the size of the wound was 79.4%. In group B, the size of the wound reduced from 5.9 cm2 to 2.4 cm2 ; percentage reduction in the size of the wound was 59.3%. In group C, the mean size of the wound was reduced from 7.1 cm2 to 4.2 cm2 ; percentage reduction was 40.8%. The depth of the wound also reduced in the entire three groups. Mean reduction in the depth of the wound in group A was 9 mm to 2 mm that is 77.7%. In group B, the percentage mean reduction was 69.0%, and in group C, it was 51.2%. CONCLUSION In present study, we have found that percentage change in the mean surface area of wound in insulin group is 79.4%. The percentage change in mean of wound surface area of wound in group B (phenytoin group) was 59.3%, which is less than insulin group. There was significant change in the depth of wound in both the group, but in insulin group, it is better than phenytoin group.
Authors and Affiliations
Sanjeev Rao M, Bhushan Kumar G. C, Anand Acharya
Keywords
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- EP ID EP220253
- DOI 10.18410/jebmh/2017/623
- Views 78
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