A comparative study of electroconvulsive therapy plus antidepressant versus anti-depressant alone in patients of depression
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 9
Abstract
Introduction: Depression is a condition characterized by poor response and prognosis, as well as, it is associated with lower quality of life of patients and higher mortality. It is predicted that depression will be listed as the second highest cause to result in huge economic burden by 2020. Published evidences suggested that approximately 30% of patients with depression do not response to treatment with at least a tricyclic antidepressant (TCA) at a minimum dose of 150 mg/day of imipramine (or equivalent drug) for 4 to 6 weeks’, which condition was defined as treatment-resistant depression (TRD) To address the issues caused by the use of antidepressant, electroconvulsive therapy (ECT), which is commonly recognized as an effective therapeutic intervention targeted at patients with TRD, was developed. Aims and Objective: To assess the effective ness of Electroconvulsive Therapy plus Antidepressant versus Antidepressant Alone In Patients of Depression. Methodology: After approval form institutional ethical committee a Randomized clinical trial was carried out at tertiary care hospital in 60 patients diagnosed as uni-polar or bi-polar depression as per inclusion criteria depression patients, after taking their written consent about explaining nature of treatment they would be received were randomly assigned into the two groups namely ECT (Electro Convulsive Therapy ) plus Citalopram and Citalopram alone respectively Result: Distribution of Depression patients as per ADAS- Cognitive scale shows at 2,6 and 12 moths mean±standerd deviation score 50±0.6, 45 ±0.8, 39±0.1 and 35±0.9, 33±1.0, 23±0.7 respectively this observed difference was statistically highly significant( p<0.000 1). Distribution of Depression patients as per MMSE - Cognitive scale shows at 2,6 and 12 moths mean±standerd deviation score were 43±0.45, 35±0.35, 32±0.23 and29±0.8, 25±0.9, 23±1.0 respectively this observed difference was statistically highly significant( p<0.000 1). Distribution of Depression patients as per UKU Scale subjected to sleep shows at 2,6 and 12 moths mean±standerd deviation score were0.75±0.5, 0.65±0.45, 0.95±0.35 and 0.44±0.23, 0.25±0.22, 0.32±12 respectively this observed difference was not statistically significant (p>0.05) Conclusion: The effectiveness of ECT plus Citalopram was higher compared Citalopram alone group with the side effects comparable to the Citalopram only group so ECT plus Citalopram should be used to treat the patients of depression than Citalopram alone
Authors and Affiliations
Nitin P Patil, Aditi N Patil, Nilesh M Naphade, Sudhir J Gaikwad, Abhishek Kumar, Chinmay V Barhale
Keywords
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