A comparative study of haemodynamic effects of propofol and etomidate used as induction agent in general anaesthesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Many anaesthetic drugs have been used as induction agent. Propofol, although most commonly used induction agent, causes significant reduction in arterial pressure. Another agent, etomidate, has advantage of minimizing hypotension. Materials and Methods: A total of fifty patients posted for surgery under general anaesthesia were taken up for the study and were randomly allocated into two groups. All patients received intravenous fentanyl citrate (2g/kg) followed by a study drug over 30-60 seconds. Propofol group (Gr P) received 2.5 mg/kg dose of propofol, and etomidate group (Gr E) received etomidate at 0.2 mg/kg. Heart Rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and SpO2 were noted at the following time intervals: before induction, at the end of induction (loss of eyelash reflex), at the end of intubation and after 5 minutes of intubation. Adverse effects such as pain on injection and myoclonus were also recorded. Results: Mean heart rate, SBP, DBP, and MAP recorded at different time intervals were lowest in Gr P. Pain on injection was significantly increased in Gr P (56%). Myoclonus was seen in Gr E (12%). Conclusion: Induction with 0.2 mg/kg of etomidate is better for its hemodynamic stability over propofol (2.5 mg/kg) along with less incidence of pain on injection. Only drawback was incidence of myoclonus.
Authors and Affiliations
Subrat Kumar Nayak, Khullem Maniram Singh2, Langpoklakpam Chaoba Singh, N Ratan Singh4, Dilip Ingudum5
Keywords
Related Articles
- EP ID EP365260
- DOI 10.9790/0853-1702150106
- Views 115
- Downloads 0
Unusual Site of Distant Metastasis in A Carcinoma Larynx Patient
Carcinoma larynx has a propensity for metastasis in neck nodes. Distant metastasis in larynx cancer are rare and the usual sites are lung, liver and bones. We report a case of carcinoma larynx post local treatment presen...
A Study on Pulmonary Function Test in Diabetes Mellitus And Its Correlation with Duration of Diabetes Mellitus.
Although diabetes is a multi systemic disorder its pulmonary involvement is not extensively studied. Pathoanatomical studies in diabetic patients have represented changes in basal lamina of alveolar epithelium and capill...
Ocular Toxoplasmosis in Benghazi, Libya: Evidence of Type I Strain
Toxoplasma gondii a tissue protozoan affecting one third of humanity has subpopulation structures in different geographical regions caused by less frequent sexual recombination and population sweeps. The majority of stra...
Rapid Maxillary Expansion- A Narrative Review
Maxillary expansion is an area where extensive researches have been performed because of its wide range of application.Many designs and modifications have been suggested by various authors since its introduction.The over...
KAP of Antibiotic Resistance among the Junior Doctors in RIMS
Introduction: WHO Defines The Appropriate Use Of Antimicrobials As “The Cost Effective Use Of Antimicrobials Which Maximizes Clinical Therapeutic Effect While Minimizing Both Drug-Related Toxicity And The Development Of...