A COMPARATIVE STUDY OF INFUSION DEXMEDETOMIDINE AND INFUSION MAGNESIUM SULPHATE ON ATTENUATION OF BLOOD PRESSURE SURGE IN LAPAROSCOPIC SURGERY UNDER GENERAL ANAESTHESIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 21
Abstract
BACKGROUND The haemodynamic surge in laparoscopic surgery following carbon dioxide insufflations can be attenuated by various drugs. Dexmedetomidine, a selective-alpha-agonist depresses central sympathetic outflow producing sedation, decreased analgesic requirement, is approved by USFDA for mechanically ventilated patients in ICU for a period of <24 hours. One of its “off label” uses is attenuation of Hemodynamic changes in laparoscopic surgery. Parenteral magnesium sulphate has been used as an antiarrhythmic and antiseizure drug in preeclampsia. It also has analgesic action on NMDA receptor, inhibits catecholamine release from peripheral nociceptors and attenuates vasopressor mediated vasoconstriction. A study was conducted to assess and compare the effects of these drugs. We wanted to study the relative efficacy of infusions of dexmedetomidine & magnesium sulphate on attenuation of hemodynamic responses in laparoscopic surgery under general anaesthesia. METHODS A prospective, double blind, randomized, comparative study was conducted on a total of 105 patients in a tertiary care teaching hospital. The three groups (n=35) were: Control (Group-C), Dexmedetomidine (Group-D), and Magnesium sulphate (Group-M). RESULTS Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were significantly lower with Dexmedetomidine group than Magnesium sulphate group at all intervals (p<0.05) The MgSo4 group however showed significantly (p<0.05) better haemodynamic control at 30 minutes compared to the control group. CONCLUSIONS Intravenous infusion with Dexmedetomidine for laparoscopic surgery under general anaesthesia is more effective than Magnesium sulphate in attenuating the cardiovascular effects of pneumoperitoneum.
Authors and Affiliations
Suchismita Mallick, Sarbari Sawika, Siddhartha Chakraborty, Subhasish Ghosh, Rajat Choudhuri
Keywords
Related Articles
- EP ID EP619141
- DOI 10.14260/jemds/2019/373
- Views 76
- Downloads 0
IDIOPATHIC INTRACRANIAL HYPERTENSION: A CLINICAL STUDY
[b]BACKGROUND AND OBJECTIVES[/b]: IIH is a disease characterized by raised intracranial pressure without ventricular enlargement or intracranial mass on imaging, with normal cerebrospinal fluid constituents. O...
A CASE OF SCRUB TYPHUS FEVER PRESENTING WITH MULTI-ORGAN FAILURE
PRESENTATION OF CASE A 25-year-old female patient with no previous co-morbidities came to General Medicine department of IGIMS, Patna, Bihar with presenting complaints of fever associated with chill and rigor for a durat...
GENITAL MOLLUSCUM CONTAGIOSUM AND HIV- A COMPARATIVE STUDY
BACKGROUND Genital Molluscum (GM) is Sexually Transmitted Disease (STD), common in young adults. Will there be any clinical differences including dissemination with HIV status? So, we compared GM clinically in HIV positi...
HIDRADENITIS SUPPURATIVA: NIDUS FOR SCROFULODERMA
Scrofuloderma is a form of cutaneous tuberculosis from direct extension of disease focus.1 Hidradenitis suppurativa is primarily a poral occlusion disease and it forms a nidus for scrofuloderma.2In this article...
DRY EYE IN PRESENT SCENARIO
PURPOSE To compare which test modality is better and less time consuming for diagnosis of dry eye. MATERIAL AND METHOD The present study was conducted on 100 subjects in Department of Ophthalmology, Index Medica...