A Comparative Study of Intrathecal Dexmedetomidine and Fentanyl as an Adjuvant to Bupivacaine
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 12
Abstract
In recent years, the use of intrathecal adjuvants has gained popularity. The quality of spinal anaesthesia is improved with addition of opioids and other drugs but no drug is without side effects. The aim of this study was to compare the addition of either Dexmedetomidine or Fentanyl to intrathecal Bupivacaine as regards the onset and duration of sensory and motor block, hemodynamic effects, postoperative analgesia and adverse effects of either drug. Sixty patients with ASA grade I and II scheduled for lower limb and lower abdominal surgeries were randomly allocated to two groups (30 patients each): Group D received 2.5 ml 0.5% hyperbaric Bupivacaine and 5 µg of Dexmedetomidine intrathecally. Group F received 2.5 ml 0.5% hyperbaric Bupivacaine and 25 µg of Fentanyl intrathecally. Patients in group F had faster onset of motor and sensory block than group D (P = 0.000). Patients in group D had significantly longer duration of motor and sensory blockade as compared to those in group F (P = 0.000). Postoperative analgesia was significantly longer in group D than group F (P =0.000). Incidence of side effects among the two groups was not statistically significant. Fentanyl has faster onset compared with Dexmedetomidine but prolonged duration of sensory and motor blockade with postoperative analgesia was seen with Dexmedetomidine without significant side effects.
Authors and Affiliations
Dr Rashmi Bengali
Keywords
Related Articles
- EP ID EP213065
- DOI -
- Views 140
- Downloads 0
Status of Serum Leptin and Lipid Profile in Newly Diagnosed Psoriasis Patients: A Case Control Study
Objective: Psoriasis is an autoimmune chronic inflammatory disease involving the skin and mucous membranes. Besides the autoimmune and genetic factors many stressful physiologic, psychological events and environmental fa...
Patient Knowledge of Conservative Management of Symptomatic Knee Osteoarthritis at Orthopedic Clinic, in SFHP, Riyadh (A Primary Health Care Prospective)
Background: Knee osteoarthritis is a joint disease that is either symptomatic or asymptomatic. Changes in structures in and around knee joint occurs in this condition. This disease is more dominant in females than in mal...
Ratio Ictal SPECT Co-registered with MRI visualizes a greater extent of the ictal onset zone in focal refractory epilepsy
Background: Until recently, the main non-invasive technique to evaluate the ictal onset zone has been Subtraction ictal SPECT coregistered with MRI (SISCOM). While SISCOM provides useful information about the ictal onset...
Prevalence of exclusive breastfeeding among recently delivered women in Block Hazratbal, District Srinagar
Background: Breast feeding is the best documented feed for the infant during the initial six months of life. It is essential for child’s optimal growth and development and also reduces the incidence of diarrhoea and pneu...
Seroprevalence of Transfusion Transmitted Infection among Blood Donors in Government Blood Banks of Chhattishgarh: Retrospective 5 Years Study
Background: Transfusion transmissible infection (TTI) is defined as any infection that is transmissible from person to- person through parenteral administration of blood or blood products. The occurrence of TTIs varies f...