A comparative study of MR spectroscopy parameters in temporal lobe epilepsy patients and healthy individuals
Journal Title: Medpulse International Journal of Radiology - Year 2018, Vol 6, Issue 3
Abstract
Background: MR spectroscopy has been shown to be useful in the preoperative evaluation of patients with temporal lobe seizures.MR spectroscopy has demonstrated consistent metabolic abnormalities in temporal lobe epilepsy. The reason for decreases in N-acetylated compounds are thought to be related to neuronal hippocampal cell loss as observed in hippocampal sclerosis. Aim: To compare MR spectroscopy parameters in temporal lobe epilepsy patients and healthy individuals. Material and Methods: A total of 25 patients with temporal lobe epilepsy and with seizure disorder were studied. MR imaging of the temporal lobes was performed on a clinical 1.5 Tesla MRI system employing standardized epilepsy protocol. The resonances of importance were identified NAA(N-acetylaspartate) at 2 ppm, Cr (Creatinine) at 3 ppm and Cho (Choline) at 3.2 ppm. Then the metabolite ratios namely NAA/ Cho, NAA/ Cr, NAA/Cr +Cho, and Cho/Cr were calculated. Results: The mean Choline value of right hippocampus of TLE patients was minimally increased and that of left hippocampus was significantly increased when compared to reference mean value of the right and left hippocampus respectively. The mean NAA/Cho+Cr value of the right and left hippocampus of TLE patients was minimally increased when compared to the reference mean value. Conclusion: A significant decrease in NAA/Cr in the diseased hippocampus was observed as compared with the control subjects. Thus, Multi Voxel MR Spectroscopy of bilateral hippocampus can be used as an important diagnostic tool in the assessment of Temporal Lobe Epilepsy.
Authors and Affiliations
Arunan Murali, T Bhasker Raj, Venkata Sai, Sheila Elangovan, J Saranya
Keywords
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- EP ID EP533518
- DOI 10.26611/101367
- Views 128
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