A Comparative Study of Ondansetron versus Ondansetron with Dexamethasone in Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Modified Radical Mastectomy with Axillary Node Dissection Under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 9
Abstract
Modified radical mastectomy surgeries used to have high incidence of nausea and vomiting. Ondansetron and Dexamethasone both used to prevent postoperative nausea and vomiting .We evaluated the efficacy of Dexamethasone in combination with ondansetron verses ondensetron alone. Methods- in a prospective double blind study of 80 patients scheduled for MRM with axillary node clearance taken in to consideration. Group O (n=40) given ondensetron 8mg alone and group D(n=40) given ondensetron 8mg with Dexamethasone 8mg. all patient have standard methods of anaesthesia and mastectomy. Episodes of PONV noted with standard 4 point scale. Observation and Results- demographic profile in both group are comparable. The PONV lower in Dexamethasone group in first 6hr period( 17.5% vs 40% p<0.05%). In 6-12 hr, the the PONV in Dexamethasone group is still lower (7.5% vs 20% p>0.05) but it is not statistically significant. In 12to 24 hr 100% patient in Dexamethasone group is completely free of PONV. There is minimal adverse effect of both of these drugs. Conclusion- Preoperative intravenous Dexamethasone (8 mg) in combination with ondansetron can significantly reduce the incidence of PONV in patients undergoing mastectomy with axillary dissection for breast cancer.
Authors and Affiliations
Alok Kumar Sahoo
Keywords
Related Articles
- EP ID EP214277
- DOI -
- Views 85
- Downloads 0
Assessment of treatment with Intravesical alkalinized lidocaine and heparin in Painful bladder syndrome /Interstitial cystitis (PBS/IC)
Introduction: Painful bladder syndrome or Interstitial cystitis (IC) is characterized by an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder and presented as urgency, f...
Comparison between Mulligan Traction Leg Raise versus Slumps Stretching on Pain, Passive Leg Raise, and Functional Disability in Lumbar Radiculopathy
Lumbar spine disorders rank 5th among the diseases categories with 37% of cost a direct case of physical therapy services. So the intervention requires a beneficial, safer, and cost effective treatment. Conservative trea...
Evaluation of Antibacterial and Cytoxicity Activities of 5-Nitro Acetyl Salicylic Acid and 5-Bromo Acetyl Salicylic Acid Compounds
Introduction: Phenolic compounds have dramatic effects in treat different various diseases caused by pathogenic bacteria. From these compounds, substituted phenolic carboxylic acids carrying active chemical groups. There...
Single Puncture CT Guided fine-needle aspiration cytology (FNAC) and Tru-cut biopsy in Indeterminate Lung Lesions
Purpose 1. To establish cytological and histopathological diagnosis of indeterminate focal and diffuse lung lesions 2. Comparison of coaxial lung FNAC and trucut biopsy 3. Combined complications of coaxial lung FNAC and...
A Clinico-Pathological Correlation Study of the Spectrum of Non-Infectious, Scaly Skin Lesions
A prospective correlation study was done on 51 patients, clinically diagnosed to have non-infectious, scaly skin lesions falling under the spectrum of Papulosquamous disorders. Thirty six of these patients were found to...