A Comparative Study of Ondansetron versus Ondansetron with Dexamethasone in Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Modified Radical Mastectomy with Axillary Node Dissection Under General Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 9
Abstract
Modified radical mastectomy surgeries used to have high incidence of nausea and vomiting. Ondansetron and Dexamethasone both used to prevent postoperative nausea and vomiting .We evaluated the efficacy of Dexamethasone in combination with ondansetron verses ondensetron alone. Methods- in a prospective double blind study of 80 patients scheduled for MRM with axillary node clearance taken in to consideration. Group O (n=40) given ondensetron 8mg alone and group D(n=40) given ondensetron 8mg with Dexamethasone 8mg. all patient have standard methods of anaesthesia and mastectomy. Episodes of PONV noted with standard 4 point scale. Observation and Results- demographic profile in both group are comparable. The PONV lower in Dexamethasone group in first 6hr period( 17.5% vs 40% p<0.05%). In 6-12 hr, the the PONV in Dexamethasone group is still lower (7.5% vs 20% p>0.05) but it is not statistically significant. In 12to 24 hr 100% patient in Dexamethasone group is completely free of PONV. There is minimal adverse effect of both of these drugs. Conclusion- Preoperative intravenous Dexamethasone (8 mg) in combination with ondansetron can significantly reduce the incidence of PONV in patients undergoing mastectomy with axillary dissection for breast cancer.
Authors and Affiliations
Alok Kumar Sahoo
Keywords
Related Articles
- EP ID EP214277
- DOI -
- Views 73
- Downloads 0
Study of Endometrial Biopsy Specimen in Women with Postmenopausal Bleeding
Background: Post menopausal bleeding is a symptom for which medical aid is usually sought as it well known that the cause may be a malignant process. Therefore, slight bleeding in postmenopausal period should be thorough...
Immunoglobulin GM and KM Allotypes Influence on the outcome of Hepatitis C Virus Treatment
Hepatitis C virus (HCV) is an endemic problem in Egypt with genotype 4 affecting about 90% of the infected patients. The treatment with interferon (IFN) and ribavirin (RBV) is costly and has various side effects, so ther...
Survival Outcome of Infants in NICU - A Three Year Review
Aim: To retrospectively review survival rates and to assess the survival outcome of infants admitted in Newborn Intensive Care Unit [NICU]. Methods: The case records of all infants admitted in NICU, from 2012 to 2014 wer...
Ketamine- The wonder drug in Status Asthmaticus
A 20 year old male was admitted to intensive care unit with status asthmaticus. Conventional bronchodilator therapy as well as mechanical ventilation failed to improve his lung dynamics. A trial of inj. Ketamine as bolus...
Comparison of Fitness of Skeletal Muscles in School Children of Urban and Rural Population
Muscular fitness is one of the important parameter for assessing the physical fitness. Poor physical fitness attributes to different diseases like diabetes mellitus, hypertension, coronary artery disease and different ca...