A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India
Journal Title: International Journal of Medical Science and Public Health - Year 2018, Vol 7, Issue 3
Abstract
Background: Cervical cancer ranks as the 2nd most common cancer among Indian women between 15 and 44 years of age. The secondary biomarker p53 has been studied at various centers in the world and has been found to be deregulated in cervical cancers. Objective: This study was undertaken to observe the expression and association of p53 and grades of p53 in premalignant and malignant cervical lesions and also with their histopathological subtypes. Materials and Methods: The present prospective study was conducted, from January 2016 to December 2016. Patients with premalignant and malignant cervical lesions of epithelial origin were included, while those with other pathological entities were excluded. A total of 53 patients were finally enroled for this study. Cases with p53 expression in more than 5% cells were considered positive for p53 overexpression. Results: The mean of p53 expression was higher in malignant lesions (13.29 ± 16.00) when compared to premalignant lesions (1.12 ± 2.23) and the result was statistically significant (P = 0.019). No statistically significant association (P = 0.875) was found between types of premalignant lesions and p53 overexpression as well as types of malignant lesions and p53 expression. Conclusion: In the present study, much higher percentage of p53 overexpression is observed in malignant than premalignant lesions, the difference being statistically significant (P = 0.009). Mean p53 expression in the malignant lesions is also higher than premalignant lesions. p53 expression is therefore a suggested marker for differentiating malignant from premalignant lesions.
Authors and Affiliations
Vinay Yadav, Milan Jaiswal, Surabhi Pandey
Keywords
Related Articles
- EP ID EP459815
- DOI 10.5455/ijmsph.2018.0100612012018
- Views 57
- Downloads 0
Breastfeeding Practices of mothers of under five years old children in Bahir Dar City, Ethiopia: A descriptive cross sectional-community based survey
Background: Improved breastfeeding practices can help in preventing diarrheal diseases and malnutrition. In Ethiopia, children are still suffering from diarrheal diseases and malnutrition. Aims & Objective: T...
An interventional study to assess the change in knowledge and attitude regarding child health care among adolescents of tribal ashram shala, Sakwar, Palghar district, by four-pronged approach
Background: Adolescents of tribal areas possess hardly any knowledge about the health care of pregnant women, and they would be future husbands and decision makers of the family. This study was undertaken to study th...
A comparison between dexmedetomidine and midazolam infusion on characteristic of spinal anesthesia
Background: Different adjuvants have been used to extend spinal anesthesia, with the probable benefits of late commencement of postoperative pain and reduced analgesic requirements. Alpha-2 adrenoceptor agonists h...
Smoking change of English-, French-, and Chinese speaking immigrants in Ottawa and Gatineau, Canada
Background: Immigrant smoking change is of particular interest to multicultural health researchers and policymakers. Objective: To examine the smoking change of the English-, French-, and Chinese-speaking immigrants...
Anti-microbial properties of human wax
Background: Bronchial asthma is one of the most common chronic diseases in Saudi Arabia, affecting more than 2 million Saudis. Poor knowledge, fear of use of new drugs, and lack of awareness of the importance of c...