A comparative study of ramosetron versus on dansetron for the prevention of post-operative nausea and vomiting at tertiary health care center
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 4, Issue 2
Abstract
Background: Postoperative nausea (PON) and postoperative vomiting (POV) are common and distressing complications after surgery. Aims and Objectives: To study ramosetron versus ondansetron for the prevention of post-operative nausea and vomiting at tertiary health care center. Methodology: After approval from institutional ethical committee this cross-sectional study was carried out in the post-operative patients undergoing various surgeries with respect to Nausea, Vomiting, Rescue medicine if required at the tertiary health care center during the one year period i.e. January 2013 to January 2014. There were 50 patients randomly enrolled into the study. These post-operative patients were randomly given ramosetron (Group A) ondansetron (Group B) -25 in the group. The no of patients having post-operative Nausea, Vomiting, Rescue medicine was noted. The statistical analysis done by Chi-square test, unpaired t-test calculated by SPSS -19 version software. Result: The mean age (yrs.) in Group A and Group B was 37 ± 4.5 and 35 ± 5.1 (Comparable to each other, P>0.05). The proportions of Males and Females was comparable in each treatment group i.e. 52% and 48% ; 60% and 40% respectively (P>0.05). Post-Operative Nausea and Vomiting in both the treatment group was not statistically significant (P>0.05), but were significantly different at 12-18 Hrs. and highly significant at 12-28 Hrs. i.e. Nausea, Vomiting, Rescue Medicine required -20 %, 12%, 8% and 56%, 40%, 28% (P<0.05); at 18-24 Hrs. 24%, 8%, 4% and 72%, 60%, 44% (P<0.001). Conclusion: It can be concluded from our study that Post-Operative Nausea and Vomiting in both the treatment group was comparable with each early post operative period but were significantly different at later post-operative period.
Authors and Affiliations
Narugula Sadanandam, Vijay Kumar K
Keywords
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