A Comparative Study of Sublingual Vs Oral Misoprostol for Cervical Ripening in First Trimester Termination of Pregnancy
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Cervical dilatation before suction evacuation is probably the most critical step in vacuum aspiration. Misoprostol is commonly used for cervical priming. Therefore, a route which provides a faster and a higher plasma level is preferable. The aim & objective of the study was to compare efficacy and safety of misoprostol administration by sublingual and oral routes for cervical priming before surgical evacuation under anaesthesia in first trimester termination of pregnancy. This hospital based randomized comparative study was conducted on 230 patients attending the Department of Obstetrics & Gynaecology, SMS Medical College, Jaipur, for first trimester termination of pregnancy from april 2012 - august 2013 . 230 patients selected for the study were allocated into two groups of 115 each ( Group A & B ). Women in Group A were administered 400 µ of Misoprostol sublingually & in Group B orally. The mean cervical dilatation achieved preoperatively in Group-A was 8.66 ± 1.92 mm and in Group – B was 8.46± 6.15 mm (p = 0.20 , significant ). The mean duration of procedure in Group – A was 213.78 ± 58.12 sec i.e 3.56 ±0.97 min and in Group – B was 254.04 ± 64.01 sec i.e 4.23 ± 1.07 min (p< 0.05, Significant). In conclusion, Sublingual route of Misoprostol is better than oral route for cervical priming before surgical evacuation with reduction in duration of surgery in first trimester termination of pregnancy. Keywords: Misoprostol, Sublingual, Oral, Cervical priming, Surgical evacuation.
Authors and Affiliations
Shalini Agarwal, Anuradha Salvi, Premlata Mital, Usha Shekhawat, Ramesh Beniwal, Pradeep Kumar Soni
Keywords
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