A Comparative Study of the Diagnostic and Prognostic Value of Squamous Cell Carcinoma Antigen and Alfa-foeto Protien in Hepatocellular Carcinoma Before and After Therapeutic Intervention
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 11
Abstract
<strong>Background: </strong>hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and it is one of the major causes of death, because of its high frequency and poor prognosis. Hepatocellular carcinoma is now a common malignancy in Egypt which usually develops on top of liver cirrhosis secondary to viral infection, as hepatitis C viruses increased the risk of HCC in the Egyptian patients. <strong>Aim of the Work: </strong>was to verify the possibility of using the plasma squamous cell carcinoma antigen level as a tumor marker for hepatocellular carcinoma and to evaluate its prognostic value in management of HCC.<strong> Patients and Methods: </strong>the study included 60 subjects divided into three groups: group I was 30 patients with hepatocellular carcinomas, group II was 15 patients with liver cirrhosis and group III was 15 normal subjects serving as a control group.<strong> Results: </strong>the plasma SCCA level was significantly higher in group I patients (with HCC), than in the group II patients (cirrhosis) and control group. SCCA showed direct significant correlation with the most of laboratory data specially AST, INR, number and size of lesion.<strong> Conclusion: </strong>plasma SCCA is a sensitive and specific serum marker for the diagnosis of HCC and combination of AFP and SCCA in screening and diagnosis of HCC yielded a better sensitivity in diagnosis of HCC.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584384
- DOI 10.12816/ejhm.2018.11542
- Views 116
- Downloads 0
Fixation of Unstable Neck Femur Fractures in Adults, Review Article
Background ː Femoral neck fracture is a common problem especially in young adults. There are different methods of fixation of unstable neck femur fractures in adults, some of which are accompanied by complications. Aim o...
Role of MRI CSF Flowmetry in Evaluation of Hydrocephalus in Pediatric Patients
Background: phase contrast MR imaging is a rapid, simple and non-invasive technique which is sensitive to even small CSF flows, and can be used to evaluate CSF flow both qualitatively and quantitatively. Cine phase contr...
Misunderstanding of Parents about using of Anti-Biotic in Upper Respiratory Tract Infection in Riyadh, Saudi Arabia
<strong>Background: </strong>Misuse of antibiotics has become a global public health issue for several reasons, one of which is the rapid development of antibiotic resistance that leads to high morbidity and mortality. <...
Effect of Aminophylline on Atracurium Induced Neuromuscular Block
<span>Background: </span><span>theophylline is a naturally occurring methylxanthine that plays a role in various body functions through different mechanisms which include: phosphodiesterase enzyme inhibition, adenosine r...
Evaluation of Tuberculosis Awareness in Eastern and Western Saudi Arabia
Background: Previously, and specifically at the last period of 20th century, TB was one of the major leading cause of death. However, the incidence of TB has been decreased. Around ten million cases have been reported in...