A Comparative Study of the Diagnostic and Prognostic Value of Squamous Cell Carcinoma Antigen and Alfa-foeto Protien in Hepatocellular Carcinoma Before and After Therapeutic Intervention
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 11
Abstract
<strong>Background: </strong>hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and it is one of the major causes of death, because of its high frequency and poor prognosis. Hepatocellular carcinoma is now a common malignancy in Egypt which usually develops on top of liver cirrhosis secondary to viral infection, as hepatitis C viruses increased the risk of HCC in the Egyptian patients. <strong>Aim of the Work: </strong>was to verify the possibility of using the plasma squamous cell carcinoma antigen level as a tumor marker for hepatocellular carcinoma and to evaluate its prognostic value in management of HCC.<strong> Patients and Methods: </strong>the study included 60 subjects divided into three groups: group I was 30 patients with hepatocellular carcinomas, group II was 15 patients with liver cirrhosis and group III was 15 normal subjects serving as a control group.<strong> Results: </strong>the plasma SCCA level was significantly higher in group I patients (with HCC), than in the group II patients (cirrhosis) and control group. SCCA showed direct significant correlation with the most of laboratory data specially AST, INR, number and size of lesion.<strong> Conclusion: </strong>plasma SCCA is a sensitive and specific serum marker for the diagnosis of HCC and combination of AFP and SCCA in screening and diagnosis of HCC yielded a better sensitivity in diagnosis of HCC.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584384
- DOI 10.12816/ejhm.2018.11542
- Views 106
- Downloads 0
Awareness of Risk Factors of Hernia among Adults in Riyadh, KSA
<strong>Background</strong>: Abdominal wall hernias are a very common surgical condition affecting all ages and both genders. The main predisposing factors of hernias include pregnancy, weight lifting, constipation, weig...
Treatment Options for Relapsing-Remitting Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the central nervous system that usually affects young adults, particularly women. The pathobiology of multiple sclerosis contains infl...
Comparison between Cyanoacrylate, Sutureless and Polypropylene Sutures in Mesh Fixation on Lichtenstein Tension free in repair of Open Inguinal Hernia
<strong>Background:</strong> inguinal hernia repair is one of the most common operations in general surgery. The Lichtenstein tension-free operation has become gold standard in open inguinal hernia repair. Despite the lo...
Assessment of Endovascular Treatment of Tibial Artery Occlusion in Diabetic Patients
<span>Background: </span><span>Globally, over 170 million people have diagnosed DM, and by the year 2030, the prevalence is estimated to raise 2.5-fold. Diabetes mellitus (DM) is one of the strongest predictors of periph...
Procalcitonin as A Diagnostic and Prognostic Marker of Sepsis in Critically Ill Patients in Intensive Care Unit
Background: Sepsis is a leading cause of mortality in critically ill patients. However, differentiating sepsis from non-infectious triggers of the systemic inflammatory response syndrome (SIRS) is difficult. Procalcitoni...