A COMPARATIVE STUDY OF THE EFFECT OF VARIOUS KINETIC PARAMETERS ONSYMMETRIC REDUCTION OF KETONES USING TETRABUTYLAMMONIUM FLUORIDE AND POLYMETHYLHYDROSILOXANE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 5
Abstract
The present work is aimed mainly to investigate and find optimal conditions by changing various kinetic parameters on reaction conversion such as duration of reaction, effect of temperature, and solvent. THFwas found to be the best solvent for this mild reduction of carbonyl compounds. These optimal conditions were applied on fundamental and practical PMHS/TBAF reduction reaction of carbonyl compounds. This study underscored the reduction of various acetophenone derivatives, 4'-haloacetophenones (X=F, Cl and Br) and 4'-nitroacetophenone andthe chemical yield could reach about 80%. The results obtained in the present studysuggest that the thePMHS/TBAFcan be used as catalyst in synthesis many pure pharmaceuticals. Thesereveald that the PMHS/TBAFis an excellent reducing agent for the mild reduction of ketones and aldehydes.
Authors and Affiliations
Lakhdar Sekhri
Keywords
Related Articles
- EP ID EP618087
- DOI -
- Views 133
- Downloads 0
ANTIDIABETIC POTENTIAL OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA NEES ON HIGH FAT DIET AND STREPTOZOTOCIN INDUCED DIABETIC RATS
The present study is to investigate the antidiabetic effect of the ethyl acetate extract of Adhatoda vasica Nees on type 2 diabetes induced by high –fat diet and streptozotocin in diabetic male Wistar albino rats. Diabet...
ANTI-OBESITY DRUGS OF KAIDEVA NIGHANTU: A LITERARY SURVEY
Obesity is a blessing of the modern age of machines and materialism. Globally, there are more than one billion overweight adults out of them more than 300 million are clinically obese. Individual habits with stressful li...
CARRAGEENAN AS RELEASE CONTROLLING POLYMER IN INSOLUBLE ANTI-PSYCHOTIC DRUG MATRIX
This study investigates the potential of three commercial carrageenans, Gelcarin GP379, Gelcarin GP911, Gelcarin GP812 (Iota-carrageenan) and Viscarin GP209, Viscarin GP109 (lambda-carrageenan) & Seaspen to be used for t...
A LOCALLY SYNTHESIZED PROBIOTIC FOR MAINTAINING IMMUNE SYSTEM FUNCTIONS IN IMMUNOCOMPROMISED NZW RABBITS
This study aimed to develop a novel probiotic, using microorganisms isolated and identified from rabbit‟s colon, for developing a nutritional supplement to maintain and treat the weaken immune system responses in immunoc...
ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC EFFECTS OF ETHANOL EXTRACT OF NIGELLA SATIVA SEEDS IN STREPTOZOCIN / HIGH FAT DIET INDUCED HYPERGLYCEMIC MICE
Objective: The present study was designed to determine the antihyperglycemic and antihyperlipidemic effect of ethanol extract of Nigella sativa seeds, in Streptozocin/high fat diet induced hyperglycemic mice. Materials a...