A Comparative Study of the Effects of Ethanolic Extract of Sesamum indicum Seeds and Mesterolone on Some Testicular Morphometry of Adult Male Wistar Rats Secondary to Ketoconazole-Induced Damage
Journal Title: Journal of Clinical Medical Research - Year 2020, Vol 1, Issue 1
Abstract
Aim: The study aimed at comparing the effects of ethanolic extract of Sesamum indicum seeds with mesterolone on some testicular morphometry following ketoconazole induced damage in Wistar rats. . Methods: Thirty-six (36) adult male Wistar rats were divided into six (6) groups of six rats each. Groups 1,2,3,4,5 and 6 were administered 1 ml of normal saline, 100 mg /kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of Ethanolic Extract of Sesamum indicum (EESI) seeds then 100 mg/kg bwt of Ketoconazole,100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole, respectively. All administrations were carried out orally and once per day. The histological slides were prepared for morphometric analyses. Results: No observed significant differences in the morphometry of the groups administered EESI and Mesterolone. However, the morphometry of the group administered EESIS and Mesterolone were significantly increased when compared with group 2 alone (P ≤ 0.05). Conclusions: The effects of the administration of ethanolic extract of Sesamum indicum seeds on the morphometry of the testis appeared to be indifferent with Mesterolone; and both EESIS. Mesterolone also appeared to have minimize the distortion of the normal dimensions of the testis caused by ketoconazole which may be due to their androgenic properties.
Authors and Affiliations
Yusuf MK*, Ibegbu AO, Alawa JN
Keywords
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- EP ID EP698952
- DOI http://dx.doi.org/10.46889/JCMR.2020.1107
- Views 88
- Downloads 0
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