A comparative study of the platelet augmentation potential of leaf extracts of Psidiumguajava with Carica papaya in thrombocytopenic rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Abstract: The aim of this study was to evaluate the platelet augmentation activity of the leaf extracts of Psidiumguajava and to compare it with that of Carica papaya and to explore the possible use of Psidiumguajavain cases of thrombocytopenia, especially in dengue fever. Thrombocytopenia was induced in Albino Wistar rats using Cyclophosphamide 25mg/kg s.c. from Day 1-3. Aqueous extracts of the leaves of Psidiumguajava and Carica papaya were administered p.o to the treatment groups from Days 1-15. Platelet counts of the rats belonging to all the groups were done on Days 1, 4, 7 and 11 and clotting time was measured on Day 15. The data was collected and analyzed using GraphPad Prism 5.Leaf extracts of both Psidiumguajava and Carica papaya were found to increase platelet counts significantly following Cyclophosphamide induced thrombocytopenia. There was no significant difference in the platelet augmentation potential between leaf extracts of Psidiumguajava and Carica papaya. The clotting time of the groups treated with both lower and higher doses of both extracts were found to be near normal.Our study suggests a potential role of leaf extracts of Psidiumguajava in improving the platelet counts in various thrombocytopenic disorders including a role in ameliorating the haemorrhagic complications of dengue fever. Keywords:Platelet augmentation, Cyclophosphamide, Psidiumguajava, Carica papaya, Thrombocytopenia.
Authors and Affiliations
Dr. Purnima Bordoloi, Dr. Diptimoyee Devi, Dr. Shreyashi Dasgupta
Keywords
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