A comparative study on measure the efficacy of midazolam in reducing the dose of propofol in co induction: A double blind ranadomized trial
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 12
Abstract
Priming principle refers to administration of a subanaestheic dose of an agent prior to its actual anaesthetic dose. Propofol is an effective substitute to midazolam for intravenous induction. The aim of the present study was to evaluate the efficacy of priming technique in relation to induction agents. Clinical efficacy in terms of dose reduction and alteration in peri-intubation haemodynamics was compared in midazolam induction and midazolam Propofol co-induction groups along with a control group. The study was carried out in 30 patients scheduled for general surgery, who were randomly divided into two equal groups. Group I received. Midazolam 0.05 mg/kg BW (20% of the pre-calculated induction dose), group II received 0.05 mg/kg normal saline. This was followed by induction with Propofol 2 minutes later in all the two groups at a predetermined rate till the bispectral index value of 45 was attained. The demographic data were comparable for age, weight and sex in both the groups. Total patients were divided into two groups with 30 patients each. It was observed that total induction dose of Propofol was significantly decreased in the study group 95 mg compared to control group 155.6 mg. Heart rate was better maintained in study group with minimal postintubation response. The values of systolic, diastolic and mean blood pressure observed at 1 min after induction also showed significant decrease in control group compared to study group. Conclusions: Propofol produces smooth, rapid, pleasant and safe induction. Priming with Propofol can be practiced due to its cost effectiveness and better haemodynamic profile and safety. The results showed a significant decrease in induction dose requirement in both the groups but haemodynamic stability during induction and intubation was more in Propofol auto-co-induction group.
Authors and Affiliations
Dr. Zameeruddin, Dr. Syed Ahamed Peerzade
Keywords
Related Articles
- EP ID EP587150
- DOI -
- Views 157
- Downloads 0
Use of ultrasound diagnosis for assessment of focal hepatic lesions in PMCH
The study to assess the role of ultrasound in estimation of focal hepatic lesions was planned in Patna Medical College and Hospital. Total 50 patients in age group of 25-65 years were enrolled in to the study. Liver was...
A study to compare the effectiveness of classical strain / counterstrain technique with ultrasound therapy and myofascial release technique with ultrasound therapy on unilateral upper trapezius trigger points
Background: Neck pain is very common in the region of the upper trapezius muscle. Highest prevalence is seen in middle aged groups. Women are more affected than men. Objective: To assess the effectiveness of classical st...
Comparative study of continuous milk feeding by Infusion pump versus intermittent bolus (Nasogastric/Orogastric tube) milk feeding in neonates
Background: Globally, about 18 million infants are born with a birth weight of <2500 gm every year. Though these infants constitute only 14% of total live births, they account for 60-80 % of total neonatal deaths. Most o...
Evaluation of different factors associated with Dipeptidyl-4 inhibitors use in diabetic patients
Introduction: The commonly used anti-diabetic drugs currently do not deal with major pathophysiological issues. Biguanides repress the hepatic glucose production, Sulfonylureas and Glinides stimulate the insulin secretio...
Comparing vascularization assessed by transvaginal sonography and colour Doppler with pelvic pain and Revised American Society for Reproductive staging in women with endometriosis
Background: Endometriosis is a disease causing severe pelvic pain. Previous data has shown that it has contributed to 15% infertility. Transvaginal Color Doppler is the noninvasive tool to assess ovarian endometrial vasc...