A Comparative Study on Placental Changes in Uncomplicated Pregnancies with Pre-Eclamptic Women
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 2
Abstract
Context: Preeclampsia is regarded as a risk factor in pregnancy and it leads to placental insufficiency. Placenta is a functional unit between mother and fetus. Thus preeclampsia causes both maternal and fetal morbidity and mortality. The present study intends to compare morphological and histological changes of placentae from uncomplicated pregnancies (the Control Group) and placentae from Pregnancy Induced Hypertension (the PIH group) . Study Design: A prospective type of study. Place and period of study: Department of Pathology, Anaesthesiology and Gynecology, S.S. Medical College, Gandhi Memorial Hospital, Rewa(M.P.) from 1stDec 2015 to 30th June 2017. Materials: 200 cases were taken, 100 placentae from uncomplicated pregnancies (the Control Group) and 100 placentae from Pregnancy Induced Hypertension (the PIH group. Method: Samples were grouped in two groups on the basis of presence or absence of Preeclampsia. All samples were studied morphologically and histologically. Result: To summarise the results of this study there was statistically significant (p<0.001) decrease in weight, thickness and mean diameter of the placentae in the PIH group along with decreased mean birth weight of the baby in the PIH group as compared to the control group. There was increase in calcification and infarction in placentae of the PIH group. Histopathological examination of placentae in the PIH group showed increased syncytial knots, basement membrane thickening, fibrinoid necrosis and villus stromal fibrosis along with decrease in the vasculosyncytial membrane, as compared to the control group. The above mentioned microscopic findings were statistically significant (p<0.001). Conclusion: In the present study all the morphological and histopathological variants of placenta are affected significantly in preeclampsia. From the findings in the present study, it is concluded that Pregnancy Induced Hypertension (PIH) had definite adverse influence on the histomorphology of placentae as compared to placentae of uncomplicated pregnancies. Usually antihypertensives are started when B.P. >160/110 mmhg, means from severe preeclampsia but early initiation of antihypertensive treatment will be helpful in improving the perinatal outcome.
Authors and Affiliations
Dr. Subhash Kumar Agrawal
Keywords
Related Articles
- EP ID EP507210
- DOI -
- Views 59
- Downloads 0
Role of Cytology in Evaluation of Neck Swellings
Background: Neck swellings include various non-neoplastic and neoplastic lesions of lymph node, salivary gland, thyroid and soft tissue. Neoplasms of neck region account for majority of cancers in India, accounting for 2...
Diagnostic Accuracy of FNAC in Relation to Histopathology in Bone Tumors
Background: Bone tumors constitute approximately 1% of all tumors affecting the human body. The key to their accurate recognition is the utilization of an integrated approach that assesses and correlates the clinical, ra...
Comparative Study of Endonasal and External Dacryocystorhinostomy in a Rural Tertiary Care Centre
Dacryocystorhinostomy is the surgical procedure done for patients with nasolacrimal duct obstruction and epiphora. It can be done in an external as well as endonasal approach. Our prospective study was conducted over a p...
Retrospective Analysis of Transfusion Practices among Surgical Specialties in a Tertiary Care Institution
Introduction: Many elective surgical procedures requires transfusion due to anticipated blood loss,. The preoperative demand for blood is often an over-assumption as shown by the Blood Bank Records. This results in pre-e...
Serum Creatine Kinase Levels in Overt and Subclinical Hypothyroidism
Introduction: Aim of present study is to assess the relationship between thyroid function and creatine kinase in patients with overt and subclinical hypothyroidism and correlation with thyroid hormone levels. Methodology...