A comparative study on serum thyroid hormone level in asphyxiated preterm and term newborn in cord blood at birth and 72 hrs of life, in a tertiary care center
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2018, Vol 4, Issue 1
Abstract
Introduction Thyroid hormone is essential for somatic growth and neurodevelopment Its level is influenced by various factors Perinatal asphyxia which altered several homones in neonate still less is known about the effect on neonatal thyroid hormone levels Our study is to evaluate the effect of perinatal asphyxia that alters the thyroid function in both term and preterm asphyxiated newborn by comparing cord blood and 72 hours venous bloodMaterials and Methods A prospective casecontrol study was carried out at Tertiary care Gayatri Hospital we evaluated thyroid function in 40 asphyxiated term newborns and 40 preterm newborns 3436 wks with with history of low apgar score at birth lt 6 at 1 and 5 min with acidosis pH lt 720 and 40 normal healthy preterm born by spontaneous vaginal delivery were taken In all the cases proper maternal and perinatal history was taken and categorized accordingly Cord blood and 72 hours after birth venous blood were collected in both babies and compared the level of thyroid hormones T3 T4 TSH via radioimmunoassayResults There was no significant difference in thyroid hormone observed in cord blood and in venous sample 72 hours after birth in asphyxiated preterm as compared to term babyConclusion Perinatal asphyxia affects thyroid function but there were less studies done so far over asphyxiated premature baby to know the association between thyroid hormone level and asphyxia as term babies So a larger study is needed to support and confirm our observationsKeywordsnbspHypoxic Ischemic Encephalopathy HIE Thyroid stimulating Hormone TSH Nonthyroidal illness syndrome
Authors and Affiliations
M. Hemasundar, V. R. V. K. Kishore, Sudhanshu Kumar Dash
Keywords
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- EP ID EP482905
- DOI 10.18231/2455-6793.2018.0003
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