A Comparison Between Intravenous And Local Tranexamic Acid In Controlling Blood Loss in Patients Undergoing Hemireplacement Arthroplasty With Bipolar Prosthesis-A Randomised Controlled Trial
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Introduction: Major orthopaedic surgeries are commonly associated with marked blood loss, and a subsequent need for blood transfusion is often encountered. The causes of bleeding are multifactorial, increased fibrinolytic activity being one of them. Administration of antifibrinolytic agents such as tranexamic acid(TA) perioperatively to stabilize the multiple microclots that form within the surgical wound. We wish to compare the effects of tranexamic acid in a preoperative dose of 15 mg/kg and effect of local tranexamic acid. Methodology: A randomised controlled study in a single blind fashion was carried out in the Department of Orthopaedics, Gauhati Medical College and Hospital, Guwahati (Assam), from August 2015 to July 2017.The study was conducted on a total of 135 patients with patients undergoing hemireplacement arthroplasty surgery with bipolar prosthesis to evaluate the role of tranexamic acid in reducing blood loss. Results: In our study, In IV group intra op blood loss was 104.50±21.82 ml while post op blood loss was 64.50±17.98 ml. so the total blood loss was 168.50±30.09ml.In local group intra op blood loss was 99.00±27.03ml while post op blood loss was 58.75±13.75 ml. so the total blood loss was 157.25±36.36mlIn control group intra op blood loss was 148.00±16.09ml while post op blood loss was 117.25±25.21ml. so the total blood loss was 265.25±34.89ml. Conclusion: After evaluating the effects of intravenous and local routes of administration of Tranexamic acid on intraoperative blood losses, blood transfusion requirements, and postoperative incidence of deep venous thrombosis in patients undergoing hemireplacement arthroplasty surgery with bipolar prosthesis we came to the conclusion that there is no difference among the routes of administration of TA given intravenous preoperatively and local intraperatively in controlling intraoperative and post operative blood loss but tranexamic acid reduces the blood loss intraoperatively and 24 hrs postoperatively by a highly significant degree, as well it causes a significant reduction in postoperative anemia and need for transfusion among these patients.
Authors and Affiliations
P. S. Chakrabarty, A. Gaikwad, P. Borah, M. Deka
Keywords
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- EP ID EP243689
- DOI 10.9790/0853-1610062031
- Views 104
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