A Comparison of 2-Methoxyestradiol Value in Women with Severe Preeclampsia Versus Normotensive Pregnancy
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Preeclampsia is a pregnancy complication characterized by high blood pressure and proteinuria. Endothelial dysfunction is a major theory suggested as its aetiology. It is caused by anti-angiogenic condition characterized by low Vascular Endothelial Growth Factor (VEGF). An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). This substance has an important role in VEGF expression. A 2-ME is suppressed in women with preeclampsia. Aim: To compare 2-ME in women with severe preeclampsia and normotensive pregnancy. Materials and Methods: A total of 80 subjects qualified the inclusion and exclusion criteria, were divided into two groups (40 each): the severe preeclampsia and the normotensive pregnancy. Blood sample was collected and examined with the ELISA 2-ME kit (Cayman). The data were compared and calculated using Fisher-Exact test to examine 2-ME differences between the two groups. Results: Women age, parity, and gestational age showed a non significant difference between both groups. Nonetheless, the BMI before pregnancy and the history of preeclampsia in the past pregnancy showed significant differences. In this study, the 2-ME value was lower in the severe preeclampsia group compared to the normotensive. Conclusion: This study concludes that 2-ME value in severe preeclampsia is lower than normotensive pregnancy. A lower 2-ME value may indicate COMT not producing enough 2-ME which in turn may cause the pre-eclampsia.
Authors and Affiliations
John Wantania, Serpil Aydoğmuş, Servet Gençdal, Sefa kelekçi
Keywords
Related Articles
- EP ID EP335916
- DOI 10.7860/JCDR/2017/21516.9603
- Views 111
- Downloads 0
Diagnosis of Acute Appendicitis using Modified Alvarado Score and Abdominal Ultrasound
ABSTRACT Introduction: Acute Appendicitis (AA) requires prompt surgery to prevent complications, and the diagnosis is mostly based on clinical features where scoring systems like Modified Alvarado Score (MAS) have been f...
MR Imaging in Idiopathic Inflammatory Polymyositis: Case Report and Review of Literature
ABSTRACT Idiopathic Inflammatory Myopathies (IIM) are a group of rare autoimmune disorders which present clinically with proximal muscle weakness. Diagnosis of IIM involves clinical history, pathological investigation, i...
A Rare Cause of Ophthalmia Neonatorum-Achromobacter denitrificans
ABSTRACT A 72-hour-old neonate presented with lethargy and eye discharge. Keratitis and corneal ulceration was present on the left side. Work up revealed early onset sepsis with meningitis and keratoconjunctivitis. A ra...
Changes in Posterior Segment Optical Coherence Tomography after Intravitreal Triamcinolone Acetonide Injection
ABSTRACT Introduction: Triamcinolone acetonide is a potent synthetic corticosteroid. It is a long acting depot preparation of triamcinolone having solely glucocorticoid activity. As a part of glucocorticoid activity, it...
Gene Therapy Applications in Dentistry: A Review
Gene therapy involves transfer of new genetic material or manipulation of the existing material for the purpose of treating human disease. It involves transfer of genetic material – ex vivo and in vivo and may conceivabl...