A COMPARISON OF NITROFURANTOIN, FLUOROQUINOLONES AND CO-TRIMOXAZOLE SUSCEPTIBILITY PATTERN AMONG THE UROPATHOGENS IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 32
Abstract
BACKGROUND Increasing antibiotic resistance in acute uncomplicated lower urinary tract infection complicates its treatment by increasing patient morbidity and rates of hospitalisation. In the present study, we have aimed at determining the spectrum of gramnegative bacteria causing urinary tract infection; their sensitivities to nitrofurantoin, fluoroquinolones and co-trimoxazole and to compare the sensitivity pattern among different organisms and among outpatients and inpatients. MATERIALS AND METHODS We retrospectively studied the susceptibility patterns of gram-negative isolates for 2 yrs. from October 2014 to September 2016 to nitrofurantoin, fluoroquinolones and co-trimoxazole. The results were analysed statistically by χ2 test. RESULTS Out of the total of 484 gram-negative bacilli isolates from urine, 300 were E.coli, 138 were other Enterobacteriaceae and 46 were non-fermenters. Overall sensitivity among the gram-negative bacilli to nitrofurantoin was 82.6%, whereas it was 51.6% to fluoroquinolones and 42.3% to co-trimoxazole. E. coli showed 92% sensitivity rate to nitrofurantoin, 52% to fluoroquinolones and 41% to cotrimoxazole. Other Enterobacteriaceae exhibited higher sensitivity rates to nitrofurantoin (81.7%) when compared to fluoroquinolones (67.9%) and co-trimoxazole (51.1%). The non-fermenters showed higher level of sensitivity to fluoroquinolones (54.4%) than to nitrofurantoin (23.9%) and co-trimoxazole (39.1%). Among the isolates from outpatients, 91.1% were sensitive to nitrofurantoin, 80% to fluoroquinolones and 58.5% to cotrimoxazole. Isolates from the patients admitted to various wards showed higher sensitivity to nitrofurantoin (81.6%) when compared to fluoroquinolones (48.7%) and co-trimoxazole (38.8%). Isolates from the ICU patients exhibited higher level of sensitivity to nitrofurantoin (60.5%) than to fluoroquinolones (36.8%) and co-trimoxazole (28.9%). CONCLUSION This study shows that nitrofurantoin is an acceptable empirical treatment for uncomplicated UTI particularly in the outpatient setup.
Authors and Affiliations
Pavithra K, Ronald A Roche
Keywords
Related Articles
- EP ID EP218683
- DOI 10.18410/jebmh/2017/371
- Views 118
- Downloads 0
CLINICAL EVALUATION AND ROLE OF BNP IN THE DIAGNOSIS OF HEART FAILURE IN PATIENTS WITH ACUTE SHORTNESS OF BREATH- AN OBSERVATIONAL STUDY
BACKGROUND Acute dyspnoea is a common clinical finding in the emergency department. A rapid and accurate investigation of acute dyspnoea is vital since treatment of dyspnoea can differ markedly depending on the initial c...
EFFICACY AND SAFETY OF CT GUIDED TRANSTHORACIC FNAC OF LUNG LESIONS OF VARIOUS SIZES AND LOCATIONS
CT guided transthoracic FNAC was done in 49 cases with an intention to evaluate the efficacy and safety of CT guided thransthoracic FNAC of lung lesions of various sizes and locations. We divided our cases according to s...
A STUDY TO ASSESS THE KNOWLEDGE AND PRACTICES REGARDING TOILET USAGE UNDER SWACHH BHARAT MISSION IN TRIBAL VILLAGES OF BASTAR, CHHATTISGARH (INDIA)
BACKGROUND The Govt. of India has launched Swachh Bharat Mission on 2nd October 2014 in order to expedite efforts towards universal cleanliness. Swachh Bharat Mission focus is to improve sanitation in rural areas, reduce...
CERVICAL SMEAR VS. HISTOPATHOLOGICAL STUDY - A COMPARATIVE STUDY OR EFFICACY OF CERVICAL SMEAR IN SCREENING OF CARCINOMA CERVIX
INTRODUCTION Cervical cancer is the third most common female malignancies worldwide. 1 Cervical screening is the process of detecting abnormal changes in the cervix before they can develop into cervical cancer. Conventio...
INCREASED INCIDENCE OF THYROIDITIS IN RECENT YEARS
A prospective study was carried out on 123 patients with enlarged thyroid swelling between 16-65 years age group, attending Department of Surgery, Sree Gokulam Medical College and research foundation, Venjaramoodu, Triva...