A comparison of survival in elderly as compare to young patients in locally advanced esophageal carcinoma treated by definitive chemoradiation.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Introduction: The benefit of definitive chemoradiotherapy (CRT) in elderly patients with locally advanced esophageal cancer is not well established .We perform a single institutional retrospective study of CRT in terms of median survival in elderly patients (age more than 60 years)as compare with young cohort(age less than 60 years) in locally advanced non metastatic esophageal cancer . Material And Methods: Total 70 patients, 38 in young age(group A) and 32 patients of elder age(group B)of carcinoma esophagus with ECOG 0-1 selected with stage II and III squamous cell carcinoma, who had undergone definitive CRT at our institute from January 2015 – June 2016. Chemotherapy was cisplatin (40 mg/m2) given concurrently on weekly basis with radiotherapy(RT). Median dose of RT was 50-50.4 Gy @ 1.8-2 Gy/#. Median age was 40 years(25-58 years) and 65 years(60-75 years) in young and elderly group respectively. Follow up is done at 3-42 months after treatment. Result: Median overall survival (OS) is 18 months (4-40 months) & 17 months (1-39 months) seen in young and elderly patients respectively. No stastically significant difference is seen in median survival in young and elderly group . Conclusion: Our conclusion is that patients with adequate functional status should not be excluded from curative CRT based on age alone.
Authors and Affiliations
H. S. Kumar
Keywords
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