A Comprehensive Review of Pulsatile Drug Delivery System
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 7
Abstract
Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery system with different drug release mechanisms.Sophisticated instrumentation,modern mathematical models and computation power have advanced the concept of drug delivery from a simple pill to a programmable time controlled smart system Pulsatile drug delivery system (PDDS) is the most interesting time - and site-specific system as per the patho-physiological need of the disease. This system is receiving increasing interest for the development of drugs for which conventional controlled drug release system with continuous release are not ideal. These drugs are having high first –pass effect or special chronopharmological needs. Pulsatile drug release profile is characterized by time period of no release (lag time) followed by a rapid and complete drug release. Diseases requiring PDDS includes asthma, peptic ulcers, cardiovascular diseases, arthritis, attention deficit syndrome in children and hypercholesterolemia. PDDS can be classified into: a) time controlled systems wherein the release of drug being controlled by the system itself (b) stimuli induced PDDS in which release is controlled by the stimuli like the pH or enzymes present in the intestinal tract or enzyme present in the drug delivery system (c) Externally regulated system in which the drug is handled and controlled by external stimuli like magnetism, irradiation, electric effect and ultrasound. Various systems like capsular systems, osmotic systems based on the use of erodible polymer or soluble coating, use of ruputurable membranes.
Authors and Affiliations
Grover Chandani , Bhatt Ganesh , Kothiyal Preeti
Keywords
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