A COMPREHENSIVE REVIEW ON NOVEL ANTIDIABETIC AND ANTIHYPERTENSIVE DRUGS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 5
Abstract
Diabetes mellitus is a common form of metabolic disorder where level of blood glucose in the blood stream raises high, because of deficiency of insulin and development of insulin resistance in diabetic individuals. It is categorize under modern age life style disorder, commonly affected by middle-aged people and the children in adolescents in most developed countries. Diabetic patients develop serious complication with the development of disease, such as obesity, risk of stroke and heart failure. Globally antidiabetic drugs formulate the second-largest market by sales in the pharmaceuticals industry after cancer. Various novel targets have identified and recently various therapeutic leads successfully completed their different phases of clinical trials such as GLP-1 agonist, DPP-IV inhibitors, SGLT2 inhibitors, and are going to be the next generation therapy for management of diabetes. Hypertension is the medical term for high blood pressure. It is dangerous because it makes the heart work too hard and contributes to atherosclerosis (hardening of arteries), besides increasing the risk of heart disease and stroke. HTN can also lead to other conditions such as congestive heart failure, kidney disease and blindness. Conventional antihypertensives are usually associated with many side effects. About 75 to 80% of the world population use herbal medicines, mainly in developing countries, for primary health care because of their better acceptability with human body and lesser side effects.
Authors and Affiliations
Samrin Khalfe
Keywords
Related Articles
- EP ID EP620704
- DOI -
- Views 166
- Downloads 0
KNOWLEDGE, ATTITUDE AND PRACTICE OF MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS (MERS-COV), AMONG MALE PRIMARY SCHOOL STUDENTS IN ALMAJMAAH CITY, SAUDI ARABIA, 2017
Background: Corona virus is a disease that affects the respiratory system. Becoming a global health problem that is primarily detected in KSA with progressive increase in cases and deaths, Objective: The aim of our resea...
EVALUATION OF IN-VITRO MEMBRANE STABILIZATION AND THROMBOLYTIC ACTIVITIES OF RAVENALA MADAGASCARIENSIS SONN
The aim of the present study was to evaluate the in-vitro membrane stabilization and thrombolytic activities of the methanolic extracts of root and leaves of Ravenala madagascariensis Sonn. Assessment of in-vitro membran...
STUDY OF STAPHYLOCOCCUS LENTUS ISOLATED FROM END STAGE RENAL FAILURE PATIENTS AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERNS
During the period from beginning of June 2014 tell end of December 2015, isolation and identification of S.lentus from end stage renal failure patients under haemodialysis therapy. A total of 400 clinical samples from 10...
ICSI OUTCOME AFTER USE OF DURIAN FOR INFERTILE MALE
Background: In vitro fertilization (IVF) cycle outcome correlates with the severity of seminal fluid analysis abnormalities as well as maternal age, number of follicles picked up and endometrial condition at time of embr...
KNOWLEDGE OF PARAMEDICAL STAFF REGARDING DRUG ADDICTION IN BAGHDAD CITY/ IRAQ
Background: Addiction is one of the complicated problems in Iraqi young population. The social and cultural dimensions of this social disease are less considered. So considering socio-cultural and environmental resources...