A CONCEPT ON THE DEVELOPMENT OF BUPRENORPHINE AUTOINJECTOR FOR SELF AND EMERGENCY ADMINISTRATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: In natural and man-made disasters, pain and infection would increase morbidity and mortality. In these situations immediate treatment is mandatory and the drug has to be absorbed faster. An auto injector would be useful. The objective of this study was to develop an analgesic auto injector with buprenorphine.Methods: The auto injector is a reusable device with a disposable drug cartridge, capable of injecting 1 or 2 ml of drug solution. Sterile water filled cartridges were made from a pharmaceutical company. Water was withdrawn from the cartridge under a laminar flow and buprenorphine hydrochloride was injected to make 0.05 mg/ml concentration. Sterility test was carried out before and after injecting buprenorphine in the cartridge by nutrient agar method and aerobic and anaerobic sterility test mediums. Buprenorphine was injected, intraperitoneally in rats through autoinjector and compared with manual injection for its efficacy as an analgesic using Eddy’s hot plate.Results: The water filled cartridge as well as the buprenorphine drug filled cartridge was found to be sterile as no growth was observed in the nutrient agar and no turbidity was observed in the sterility test mediums. The analgesic effect of buprenorphine by autoinjector was found to be significantly (Kruskal Wallis ANOVA) more than manual injection and control group (median analgesic time in seconds, Control-4.0; manual injection–7.0; autoinjector–12.0).Conclusion: Water filled cartridge could be converted to drug filled cartridge aseptically. Buprenorphine administered through autoinjector was better as an analgesic than manual injection.Â
Authors and Affiliations
D. Sheela, R. V. Geetha, S. Krishna Mohan, R. Vijayaraghavan
Keywords
Related Articles
- EP ID EP578318
- DOI -
- Views 60
- Downloads 0
IN VITRO EVALUATION OF THE ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIPROLIFERATIVE ACTIVITIES OF THE LEAF EXTRACTS OF EXCOECARIA AGALLOCHA L.
Objective: To evaluate the antioxidant, anti-inflammatory and antiproliferative activities of the leaf extracts of Excoecaria agallocha L.Methods: To estimate the antioxidant effect of the extract from Excoecaria agalloc...
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-HPLC ASSAY METHOD FOR AZACITIDINE AND ITS BULK DRUG
Objective: A novel gradient reverse phase High Performance Liquid Chromatographic (HPLC) method was developed for the quantification of Azacitidine impurities and degradation products in the Azacitidine tablets.Methods:...
DETERMINATION OF ETILEFRINE HYDROCHLORIDE, FENOTEROL HYDROBROMIDE, SALBUTAMOL SULPHATE AND ESTRADIOL VALERATE USING SURFACE PLASMON RESONANCE BAND OF SILVER NANOPARTICLES
Objective: The aim of this work was to evaluate a simple, sensitive, effective and validated procedure for the determination of etilefrine hydrochloride, fenoterol hydrobromide, salbutamol sulphate and estradiol valerate...
ASSESSMENT OF CYP2D6*10 POLYMORPHISM WITH POST HERPETIC NEURALGIA PATIENTS UNDERGOING TRAMADOL TREATMENT
objective: To evaluate association of CYP2D6*10 polymorphism with respect to demographic characteristics (age at onset, genders and weight), numerical rating scale (NRS) for measuring pain intensity in relation with rest...
ANTIBACTERIAL ACTIVITY OF GREEN TEA EXTRACT IN COMBINATION WITH CEFOTAXIME ON DIARRHEA CAUSING ESBL PRODUCING E. COLI
Objective: Owing to the continuous evolution of antibiotic resistance, treatment with natural products represents significant adjuncts or alternatives to conventional antibiotic therapy. Enterobacteriaceae especially Esc...