A CONCEPTUAL STUDY OF MADATYAYA WITH SPECIAL REFERENCE TO ALCOHOLISM.
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 4
Abstract
Alcohol is the most widely abused substance worldwide, alcoholic beverages such as wine, beer, and hard liquor—contain a depressant drug called ethyl alcohol (or ethanol). The concentration of the drug varies with the type of beverage (wine and beer have less pure alcohol per ounce than distilled spirits such as rye, gin, or vodka). Alcohol is classified as a Inebriant poison which are characterized by two sets of symptom i.e. excitement and narcosis, the stage of excitement being well marked in some and that of narcosis in others.1 Alcohol addiction is considered when consumption of heavy dose of ethyl alcohol beverages for a long period, regularly and characterized by morbid desire to drink alcohol. Prolonged and excessive use of A Psychological addiction then refers to how the individual can become mentally dependent on certain substances (usually mind altering) or behaviors. Even when the individual realizes the harm that alcohol and drugs are causing them they may continue to use because of these psychological symptoms – willpower alone is often not enough to overcome a psychological addiction. To say that an individual is physically addicted on a substance means that they have an increased tolerance for it, and they will experience physical symptoms should they try to stop or reduce their intake substantially. These physical symptoms are more commonly referred to as withdrawals symptoms. The way this usually happens is that the person develops a psychological dependence first of all, and this drives them to keep using the drugs until they become physically addiction as well. A Craving can be defined as an intense desire for some particular things. It is the hallmark of psychological dependence. If the individual attempts to eliminate their addiction, or cut down on their usage, they will experience cravings. Alcohol withdrawal syndrome is a set of symptoms occurred when addicted individual reduces or stops alcoholic consumption. The withdrawal syndrome is largely a hyper-excitable response of the central nervous system due to lack of alcohol. Typical symptoms of withdrawal include nausea, vomiting, tremors, anxiety, agitation, paroxysmal sweating, disorientation, headache and hallucination. The habit of alcohol consumption leads to its addiction and causes alcohol intoxication. The habit of alcohol consumption leads to its addiction and causes alcohol intoxication. Nowadays, alcohol abuse is widespread in most parts of the world and in the current scenario; alcohol addiction is one of the major problems faced by the society. Excess alcohol intake affects every organ of the body. Alcohol Consumption is a contributory cause of more than 200 illnesses defined by the International Classification of Diseases (ICD‐10) as three‐Digit disease codes.2 In a longer perspective, drinking also leads to social problems in the home such as spouse and child abuse or family breakup, and to economic problems and loss of jobs due to instability at work. Finally, fetal alcohol syndrome is a serious condition of infants whose mothers have consumed large amounts of alcohol during pregnancy. Chronic use of alcohol causes hemorrhagic gastritis, hepatitis, cirrhosis of liver, pancreatitis, peripheral neuropathy, Wernicke‘s korsakoff syndrome, arrhythmia, holiday heart syndrome, decrease sperm count & erectile capacity, amenorrhea and low bone density. 3. In Ayurveda there is too much matter about Mada, Madya, and Madatyaya but there is lacuna in describing Panaapkram and De-addiction method. So it needs to evaluate, elaborate and develop better Ayurvedic drugs and method for De-addiction of Alcohol. That can be suitably applied on alcoholic patient with effectiveness. Taking into consideration of the above description for the de-addiction of alcohol we have to choose the drug which has anticraving effect, subside the withdrawal effect of alcohol, and correct the deleterious effects of chronic use of alcohol. Vidarikanda (Pueraria tuberosa) is also known as Indian kudzu will be act as an anti-craving agent in alcohol withdrawal as it belonging to same genus Pueraria like kudzu (Pueraria lobata). Vidarikanda and Kudzu have same useful part (root), similar chemical constituent like Isoflavonoid. Kudzu and its alkaloid isoflavonoid have proved his anti-craving property. Hence Vidarkanda will be used as successfully to lessen the craving of alcohol. Also vidarikanda have Immunomodulting, Antioxidant, Cardiotonic, Aphrodisiac, Rejuvenation, Nootropic effect which help to cope out from withdrawal syndrome and chronic bed effect of alcohol. The drug like Sarpgandha (Rauwolfia serpentina) involve in this trial to calm down the clinical manifestation like insomnia, anxiety and agitation. Also sarpagandha is indicated for the treatment of Madatyaya.7 Sudden withdrawal of alcohol may cause Agnimandya (Indigestion) by impairing metabolism, hence Phaltrikadi Churna8 added in this trial. Prolonged alcoholism causes hepatic injury and hence Bhumiamalaki Ghanvati will be added to regulate the hepatic functions and also it has vishahar property9. Thus in this clinical trial patient of alcohol withdrawal will be managed by anti-craving agent along with sedative, liver tonic and appetizer to improve the hepatic function and general health. There are so many research work had completed on Madatyay with single drug study like Kharjooradi mantha, Ashthaanga lavanayukta takra, Punarnavadi Ghruta, Mrudvikadi Kasayam, Shreekhandasava in madatyaya, Shunthi Dhanyak Toya, Laghupanchamula Kasayan in Vataja madatyay, Usheeradi Panak, Draksadi Panak in Pittaja Madatyaya and Ashtang Lavana in Kaphaja madatyaya in different -different trial work. But there is no work on protocol for de-addiction. In present study we are draw a basic Ayurvedic module to de-addict the alcoholic patient in one group and on second hand along with this vidarikand churna is taking. So we can evaluate the role of vidarikanda in alcohol de-addiction on other hand effectiveness of herbal formulation of our basic module in alcohol de-addiction.
Authors and Affiliations
Dr. Dinesh Kumar Kumawat
Keywords
Related Articles
- EP ID EP620612
- DOI -
- Views 132
- Downloads 0
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF VORICONAZOLE AND ITS RELATED SUBSTANCE IN PARENTERAL DOSAGE FORM
An Isocratic Reversed-Phase High Performance Liquid Chromatographic (RP-HPLC) method has been developed and validated for the determination of Voriconazole and its related substance in parenteral dosage form. The method...
EFFECT OF METHIDATHION ON SOME BLOOD PARAMETERS AND LIVER ENZYMES IN LABORATORY MICE MUS MUSCULUS L
The present study aimed to investigate the effect of methidathion on blood parameters and liver enzymes in mice when injected by two doses. Adult male and female mice divided into three groups for each sex (8 for each gr...
EVALUATION THE ACTIVITY OF GLUCO HERB DM2 AS NATURAL DRUG AGAINST DIABETES MELLITUS (TYPE 2) AS COMPARISON STUDY WITH METFORMIN DRUG
Over the last century, food habits and human life style have drastically changed which lead to various chronic disease. Diabetes mellitus is one such disease which is causing serious problems to human heath. Hence focus...
A REVIEW ON BANANA PLANT: A BOON TO HUMANKIND
Traditional uses of medicinal plants are very common to treat variety of diseases in various regions of word. The banana is one of them and cultivated from ancient times. The ripen fruits are used as a rich source of nut...
CHEMOTHERAPY TREATMENT IN THE COMMUNITY-BASED ONCOLOGY UNITS VERSUS TERTIARY ONCOLOGY UNITS: A CROSS SECTIONAL AND OBSERVATORY STUDY
Introduction: Cancer treatment involves comprehensive multimodality approaches and sometimes lasts for several months. Patients' daily agenda, in oncology care units, is long and exhausting. Such agenda may lead to menta...