A Connectivity between LRP-1 and Alzheimer’s Disease: Modulating the Transport and Clearance of Tau and Aβ Clearance from the Brain to the Liver
Journal Title: Advances in Clinical Toxicology - Year 2023, Vol 8, Issue 4
Abstract
A paucity of knowledge exists in our understanding of the axonal clearance of both beta amyloid (Aβ) and Tau proteins to the liver. Peripheral clearance by the liver can remove 40–50% of Aβ burden in the brain through the glial-lymphatic (glymphatic) system, transport across the blood brain barrier and mediated by low-density lipoprotein receptor-related peptide 1 (LRP-1). The lack of LDL receptors (LDLR) enhances amyloid deposition in the brain while LDLR overexpression increases the rate of Aβ entering the hepatic system. It’s important to consider the effects of organ failure on the development of AD. There are four main factors which contribute to clearance from the body. Blood flow, transport across the blood brain barrier, uptake into the liver, and elimination from the body through bile excretion all play an important role in the clearance of bioaccumulated toxic Aβ and Tau AD inducing proteins.
Authors and Affiliations
Tackett AN and Duffy L*
Keywords
Related Articles
- EP ID EP752295
- DOI 10.23880/act-16000281
- Views 17
- Downloads 0
News Media Coverage of Snakebite Incidence in Nepal during 2010–2022
Background: Despite snakebite being a medical emergency, it is still a neglected health issue in Nepal. Further, there exists gap of knowledge on snakebite epidemiology. Therefore, an analysis of incidence of snakebites...
Toxicological Diagnosis of Severe Neutropenia Due to Levamisole
Introduction: Levamisole toxic syndrome may include several effects, such as bone marrow suppression, severe agranulocytosis, neurological symptoms, or cutaneous vasculitis. Methodology: This report emphasizes the impo...
Safeguarding Public Health: The Imperative of Strong Toxic Substance Regulations
The increasing prevalence of toxic substances in our environment poses significant challenges to public health. This editorial examines the importance of robust public health policies related to toxic substance regulatio...
Strategic Assessment of Rational Drugs use in Tertiary Care Hospital Peshawar, Pakistan
Background: Rational drugs are safe, effective and medico-socio-economical for the patients. The rational use of drugs required to achieve the optimal state of the patient by community affordable cost, the “WHO” indicat...
The Role of Nerve Growth Factor in Alergic Reactions and Healing Process of Tissues
Nerve growth factor is a protein which regulates the differentiation and survival of nerve system. It is produced in neurons and in several non-nervous cells which are involved in some inflammatory and immunological stat...