A Connectivity between LRP-1 and Alzheimer’s Disease: Modulating the Transport and Clearance of Tau and Aβ Clearance from the Brain to the Liver
Journal Title: Advances in Clinical Toxicology - Year 2023, Vol 8, Issue 4
Abstract
A paucity of knowledge exists in our understanding of the axonal clearance of both beta amyloid (Aβ) and Tau proteins to the liver. Peripheral clearance by the liver can remove 40–50% of Aβ burden in the brain through the glial-lymphatic (glymphatic) system, transport across the blood brain barrier and mediated by low-density lipoprotein receptor-related peptide 1 (LRP-1). The lack of LDL receptors (LDLR) enhances amyloid deposition in the brain while LDLR overexpression increases the rate of Aβ entering the hepatic system. It’s important to consider the effects of organ failure on the development of AD. There are four main factors which contribute to clearance from the body. Blood flow, transport across the blood brain barrier, uptake into the liver, and elimination from the body through bile excretion all play an important role in the clearance of bioaccumulated toxic Aβ and Tau AD inducing proteins.
Authors and Affiliations
Tackett AN and Duffy L*
Keywords
Related Articles
- EP ID EP752295
- DOI 10.23880/act-16000281
- Views 2
- Downloads 0
Epigenotoxicity of Endocrine-Disrupting Chemicals Makes Inroads to a Paradigm Shift in the Risk Assessment of Pesticides
The most ferocious chronic effect a pesticide could have is disrupting the functions mediated by the endocrine system. When this happens during early development of the life cycle, it leads to profound and lasting adver...
Sled Dogs as a Model for Brown Fat Research
Brown adipose tissue (BAT) has the unique function of burning energy to create heat through the process of non-shivering thermogenesis. Activation of BAT in humans as a means of combating obesity is an active area of re...
Formulation of Methotrexate Loaded Polymeric Zn-Nanoparticle: An Efficient Anti-Cancer Nano-Drug
The objective of this research was to formulate, characterize, interpret and study in-vitro drug release of methotrexate (MTX) polymeric nano-drug. Methotrexate is frequently used antineoplastic drug for chemotherapy. T...
Alterations in the Air Pollution Tolerance Indices and Foliar Micro-Structures of Five Medicinal Plants: Implications of OilSpill Pollution of Agricultural Farmland in Edugberi Community, Rivers State, Nigeria
The Nigerian costal environment has witnessed the continuous input of petroleum hydrocarbons and associated pollutants as a result of different phases of petroleum activities. These activities have elicited a devastatin...
Oxytocin: The Neurohormone
Oxytocin is a peptide hormone, which serves important functions in body including labor management and lactation. Indiction of milk ejection and easy delivery there are many other aspects of in vivo oxytocin functions....