A CONTROLLED RELEASE MICROSPHERE FORMULATION OF AN ANTI-DIABETIC DRUG AND CHARACTERIZATION OF THE MICROSPHERE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 10
Abstract
Objective: Here the objective of this study was to prepare and characterize sustained release metformin loaded microsphere formulation which was prepared by W1/O/W2 emulsion solvent evaporation technique.Methods: Guar gum and sodium alginate were used as a matrix building material, whereas ethyl cellulose was applied as a coating polymer. Here various formulations were prepared by changing the drug and guar gum ratio, and the subsequent drug entrapment efficiency (DEE) and drug release were compared and evaluated.Results: Scanning Electron Microscopy (SEM) studies revealed spherical particles with a smooth appearance. Fourier-transform infrared spectroscopy (FTIR) showed there was no interaction between the ingredients in the final formulation. X-ray Diffraction (XRD) studies showed the emergence of polymorphic forms in the final formulation. The drug entrapment in the final drug loaded microsphere formulations was varied from 30-66.78%. The drug release studies showed the continuous release of the drug through twelve hours. The optimized formulation (f2) found to release 71.5% of drugs at the end of the 12th hour following zero order release kinetics.Conclusion: The increase in gum concentration in the W1 phase, which enhances viscosity in the W1 phase, resulting in an increase in the drug entrapment up to an optimum level and a decrease in the release rate. So, it can prolong the action. So by using this tool, we can say that metformin loaded microsphere formulation would be a suitable pharmaceutical formulation for the treatment of diabetic patients in modern drug therapy for its prolonged action. Â
Authors and Affiliations
Biplab Kumar Chakra, Saumen Karan, Biswajit Das, Souvik Debnath, Tapan Kumar Chatterjee
Keywords
Related Articles
- EP ID EP566124
- DOI 10.22159/ijpps.2018v10i10.27541
- Views 68
- Downloads 0
EPITOPE PREDICTION AND STRUCTURAL ANALYSIS OF PRA ANTIGEN OF COCCIDIOIDES
Objective: Coccidioidomycosis is a life threatening human respiratory disease caused by Coccidioides immitis and C. posadasii. As the incidence of symptomatic Coccidioidomycosis increases worldwide, vaccine development...
ANTIHYPERTENSIVE ACTIVITY ETHANOLIC EXTRACT OF BULB ELEUTHERINE AMERICANA MERR ON FRUCTOSE-INDUCED HYPERTENSION RATS
Objective: This study aimed to evaluate ethanolic extract of bulb of Eleutherine americana Merr as antihypertensive.Methods: This study examined the effect of ethanol extract of bulb of Eleutherine americana Merr on urin...
TOXICOLOGICAL AND PHARMACOLOGICAL ASSESSMENT OF GOLD NANORODS IN NORMAL RATS
Objective: assessment of acute, subchronic and chronic toxicity of pegylated gold nanorods (PEG-gold NRs) in Wistar rats of both sex in three routes of administration {intravenous (IV), intramuscular (IM) and subcutaneou...
ANTIMICROBIAL ACTIVITY OF OLIGOMERIC β–DEFENSIN ISOLATED FROM HEART TISSUE OF CAPRA HIRCUS
Objective: The aim of the present study was to isolate an antimicrobial peptide from heart tissue of Capra hircus (Goat) and to check its antibacterial activity against antibiotic resistant and antibiotic sensitive bacte...
BIODIVERSITY OF ANTIBIOTIC-PRODUCING SOIL BACTERIA FROM YOGYAKARTA SPECIAL PROVINCE INDONESIA
Objective: The present study aims to evaluate the diversity of antibiotic-producing soil bacteria from Java, Indonesia.Methods: An agar diffusion method to select the active isolates against Staphylococcus aureus ATCC 25...