A Convenient Synthesis of Quinazoline Acetamide Incorporated Pyrazole And Pyrimidine Derivatives And Their Antibacterial Activity
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 9
Abstract
A facile synthesis of novel chalcones (E)-3-(4-chlorophenyl)-N-(4-(2,4-dioxo-dihydroquinazolin3(4H)-yl)phenyl)acrylamide (2a,b) has been achieved by the condensation of isatoic anhydride, aromatic ketones with different aldehydes. These chalcones on cyclization with hydrazine hydrate, phenyl hydrazine in the presence of glacial acetic acid and guanidine hydrochloride in the presence of alkali to afford corresponding acetyl pyrazoline (3a,b) phenyl pyrazoline (4a,b) and amino pyrimidines (5a,b) respectively. All synthesised compounds were fully characterized by spectral studies and elemental analysis. Antibacterial activities of the final compounds have been Sent for bacterial growth.
Authors and Affiliations
P. Subashini, S. Syed Shafi
Keywords
Related Articles
- EP ID EP414401
- DOI 10.9790/5736-1109013943.
- Views 148
- Downloads 0
New Spectrophotometric Determination of Esomeprazole in Bulk And Pharmaceutical Dosage Form Using Tropaeoline-OO
The new, selective and sensitive visible spectrophotometric method has been developed for the estimation of Esomeprazole in bulk and in pharmaceutical preparations. This method is based on the reaction with tropaeoline-0...
Synthesis, Spectroscopic and Physico-chemical Studies and X-Ray Structure determination of a Metal transitions Complexes from ligand generated by benzoylpyridine
Metals transition complexes, [M(Li )(H2O)2] . (X)2 . (H2O)n, (M= Mn, Ni, Cu or Zn; i=1 or 2; n=0, ½, 1 or 2) where L1 is the neutral tridentate Schiff base (E)-N 1 -(2-(phenyl(pyridin-2-yl)methyleneamino)ethyl)ethane1,2-...
Synthesis, Growth and characterization of L-Histidine doped Potassium dihydrogen Phosphate(LHKDP) crystals.
L-histidine doped potassium dihydrogen phosphate (LHKDP) single crystals are grown by slow evaporation technique method. The addition of amino acid to KDP influences the characterization of pure KDP crystals. There is a...
Chemical Speciation of Selected Heavy Metals In Roadside Soils At Intersections And Terminuses In Harare, Zimbabwe
Sequential extraction technique was applied for the speciation and evaluation of the bioavailability of trace heavy metals in the roadside soil of major highways and terminuses in Harare, Zimbabwe. Heavy metals studied a...
Isotherm Modeling Of Lead (II) Adsorption From Aqueous Solution Using Groundnut Shell As A Low-Cost Adsorbent
Potentially toxic trace elements such as lead when present in high levels in water, food and soil post serious human health threats all over the world. Adsorption process using different natural materials is among the mo...