A Convenient Synthesis of Quinazoline Acetamide Incorporated Pyrazole And Pyrimidine Derivatives And Their Antibacterial Activity
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 9
Abstract
A facile synthesis of novel chalcones (E)-3-(4-chlorophenyl)-N-(4-(2,4-dioxo-dihydroquinazolin3(4H)-yl)phenyl)acrylamide (2a,b) has been achieved by the condensation of isatoic anhydride, aromatic ketones with different aldehydes. These chalcones on cyclization with hydrazine hydrate, phenyl hydrazine in the presence of glacial acetic acid and guanidine hydrochloride in the presence of alkali to afford corresponding acetyl pyrazoline (3a,b) phenyl pyrazoline (4a,b) and amino pyrimidines (5a,b) respectively. All synthesised compounds were fully characterized by spectral studies and elemental analysis. Antibacterial activities of the final compounds have been Sent for bacterial growth.
Authors and Affiliations
P. Subashini, S. Syed Shafi
Keywords
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