A correlational Study of Serum Ferritin Levels with Glycemic Status in Type 2 Diabetes Mellitus
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 3
Abstract
Introduction: Type 2 Diabetes Mellitus (DM) is the most common endocrine disease-a metabolic disorder of multiple etiologies. The relationship between iron metabolism and type 2 DM is bidirectional. Iron is a potent pro-oxidant that increases cell oxidative stress causing decreased insulin internalization and actions resulting in hyperinsulinemia and insulin resistance.The aim of this study is to estimate serum ferritin levels and to see for its correlation with good glycemic control. Materials and methods: It was a case control study. Fifty (50) diagnosed cases of type 2 DM and fifty (50) age and sex matched healthy controls were included. Venous blood sample was analysed for serum fasting blood sugar (FBS), post prandial blood sugar (PPBS), serum ferritin, glycosylated haemoglobin (HbA1c) in both cases and controls. Statistical analysis was done using student 't' test. Pearson's correlation was performed to establish the relationship between study variables. Results: The study showed statistically significant increase (p<0.05) in serum ferritin levels in cases compared to controls. Our study showed a positive correlation between ferritin and blood sugar levels. Conclusion: Type 2 Diabetes mellitus is associated with increased ferritin levels. Reliable and sensitive methods need to be developed to precisely measure catalytic iron that participates in oxidative injury.
Authors and Affiliations
Arati Ganiger, K Mallikarjuna Swamy, Shankar Prasad DS
Keywords
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