A CORRELATIVE STUDY OF MICRO ALBUMINURIA IN RHEUMATOID ARTHRITIS AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN THANJAVUR MEDICAL COLLEGE, SOUTHERN REGION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 43
Abstract
BACKGROUND This study was done to assess the subclinical renal involvement in Rheumatoid Arthritis (RA). To study (1) The prevalence of micro albuminuria in patients having rheumatoid arthritis. (2) The relationship between micro albuminuria and disease activity in rheumatoid arthritis as assessed by DAS28, ESR, CRP, RA factor, disease duration and constitutional symptoms. MATERIALS AND METHODS Descriptive type of cross-sectional study involving 60 patients attending Thanjavur Medical College, Thanjavur, and Rheumatology outpatient department, Thanjavur Medical College, Thanjavur diagnosed with RA by modified ACR criteria (1987). All the patients were tested for micro albuminuria by immunoassay method. RESULTS The mean age at diagnosis was 44.55 years (SD 13.767), females diagnosed at an earlier age than males (43.767 years (SD- 14.128) vs. 46.529 years (SD-13.005)). 71.7% were females and 28.3% were males. MA was found in 19 patients (31.7%), of them, 16 patients had morning stiffness lasting for more than one hour, 18 patients had constitutional symptoms, and 10 patients were on treatment with NSAIDs or DMARDs. The mean duration of symptoms was 24.68 ± 12.06 months in MA positive group when compared with MA negative group with a mean value of 14.732 ± 8.093 (p-0.0004). The mean number of swollen joints in MA positive group was 15.89 ± 5.64 as compared to MA negative Group with a mean of 11.76 ± 6.31 (p-0.018). The mean number of tender joints involved in MA positive group was 14.32 ± 6.64 as against 9.76 ± 6.25 in MA negative group (p- 0.0125). In MA positive group, mean ESR was 80.16 ± 26.67, mean CRP was 25.65 ± 22.67, mean RA Factor level was 187.947 ± 141.269 and mean DAS28 was 6.73 ± 0.65 as compared to 50.12 ± 29.19, 17.22 ± 15.37, 73.627 ± 64.398 and 5.2 ± 0.63 respectively in MA negative group (p < 0.05 (in all cases). CONCLUSION Micro albuminuria is commonly seen in Rheumatoid Arthritis. The Association between micro albuminuria and Rheumatoid Arthritis disease activity as estimated by means of DAS28, ESR, and CRP, is statistically significant. Micro albuminuria is also associated with Rheumatoid Factor, disease duration and constitutional symptoms.
Authors and Affiliations
Ganesan C, Kannan V. P, Paranthakan C
Keywords
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- EP ID EP219917
- DOI 10.18410/jebmh/2017/513
- Views 83
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