A Cost-effectiveness Study of the Quadrivalent HPV6/11/16/18 Vaccination in a Two-dose Scheme in Girls of 9-11 Years Old Compared to Bivalent HPV 16/18 Vaccination in Ecuador and Challenges for Public Health and Screening
Journal Title: International STD Research & Reviews - Year 2017, Vol 6, Issue 1
Abstract
Aims: Assess the incremental cost-effectiveness of the quadrivalent HPV6/11/16/18 vaccination as administered in a two-dose scheme to girls between 9 and 11 years old, as compared to the bivalent HPV 16/18 vaccination administered in Ecuador, and to estimate the cost-saving of preventing GW while preventing cervical cancer with both vaccines. Study Design: We used a previously developed transmission dynamic mathematical model to evaluate the impact of routine vaccination of 9-11 year-old females. The model assumed coverage of 90% for two doses of HPV6/11/16/18 vaccine at international price rates versus HPV16/18 vaccine and costs for genital warts treatment. Other simulation parameters include: country socio- demographic variables, sexual behavior and screening parameters among Ecuadorian girls. Results: Over a 100-year period, HPV6/11/16/18 vaccination would result in reductions of HPV 6/11-related disease incidence at the population level as follows: genital warts in females (81.3%), genital warts in males (78.9%) and HPV6/11-related CIN1 (79.7%). These results would translate into a reduction of HPV 6/11-related disease cost of between 52% to 56% for genital warts among females, genital warts among males, and HPV6/11-related CIN1. Under the model assumptions, the estimated net cost of vaccination with the HPV6/11/16/18 vaccine from a public health perspective would be close to -USD$256 million. Adjusted to the net present value, this cost-saving represents USD$180,735,849.09 with a present value interest factor of 0.9512. Conclusions: In Ecuador, routine vaccination of 9-11 year old females with a quadrivalent HPV6/11/16/18 vaccine is cost-saving compared to a bivalent HPV 16/18 vaccine, which suggests a significant public health and economic impact.
Authors and Affiliations
Maria Isabel Roldós, Isabel Espinosa, Amit Kulkarni, Matthew Pillsbury, Andrew Pavelyev, Homero A. Monsanto, Diego Guarín, Miguel Cashat-Cruz
Sexually Transmitted Diseases: Knowledge and Perceived Prevalence of Symptoms in University Students
Background: Research addressing knowledge on sexual health, particularly of STDs risk and perceived symptoms’ prevalence, among university students around the world, and particularly in Portugal, is scarce. Aims: The aim...
The Integration of HIV/AIDS and Non-communicable Disease Policies
Developing countries are currently facing a double burden of communicable diseases, like HIV/AIDS, and chronic non-communicable diseases (NCDs). As HIV/AIDS has already turned out to be a chronic disease, the approaches...
HIV Knowledge and Its Association with Sexual Risk Behaviours among Out-of-school Adolescents in Kumba, Southwest Region of Cameroon
Background: Cameroon has a high concentration of out-of-school youth. Therefore research relating to out-of-school adolescents and HIV/AIDS is imperative. This study investigated the HIV/AIDS knowledge and its associatio...
Youths' Reproductive Health and Risk Perception to Sexually Transmitted Infections in Communities in Bayelsa State, Nigeria: A Qualitative Study
Aims: Young people especially in sub-Saharan Africa are at great risk of contracting HIV. Studies have shown that young people aged 15–24 account for an estimated 45% of new HIV infections worldwide while less than half...
Trends in Hysterectomy for Pelvic Inflammatory Disease - Experience From Low Resource Settings
Background: Genital infections are increasing. So more women are likely to have sequelae, which sometimes leads to hysterectomy. Continuous research is essential to prevent sequelae and morbidities related to therapy for...