A cross-sectional study of coagulation parameters in normal and high risk pregnancy
Journal Title: Journal of the Indian Medical Association - Year 2019, Vol 117, Issue 4
Abstract
To asses coagulation parameters Prothrombin time, Activated Partial Thromboplastin Time, Thrombin Time, D-dimer in pregnant women. A cross sectional study of 282 patients attending antenatal outpatient department at AIIMS, New Delhi were recruited. Among the 282 subjects, 251 were pregnant and 31 were controls. Plasma was tested for coagulation parameters Prothrombin time (PT), Activated Partial Thromboplastin Time (aPTT), Thrombin Time (TT), D-dimer using Sysmex CA-1500 automated coagulation analyser. The study included 282 women of which 31 were non pregnant while 251 were pregnant. The value of PT was within the normal range (10-12 seconds) during all the three trimesters, while it was on the lower side of normal in the third trimester. The value of APTT was within the normal range (24-40 seconds) during all the three trimesters, however the value was highest during the second trimester. The value of TT was within the normal range (15-23 seconds) during first and third trimester while the second trimester showed marginal rise in the value. D-dimer was normal (<0.5microg/ ml) in the second trimester while the first and third trimester showed increased value. Normal pregnancy causes an alteration in coagulation with prothrombin time, activated partial thromboplastin time, Thrombin time which asses the extrinsic, intrinsic and common coagulation pathway respectively were within the normal limits throughout pregnancy while D-dimer an assay of fibrin degradation products showed higher values during the first and the third trimester
Authors and Affiliations
JB Sharma, Subhadra Sharma, Usha BR, Rupali Awale, Ashish Gupta, Sunesh Kumar, Asok K Mukhopadhyay
Keywords
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