A Demographical Assessment of Different Insulin Regimens in Non-insulin Dependent Diabetics
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 17, Issue 1
Abstract
A Demographical Assessment of Different Insulin Regimens in Non-insulin Dependent Diabetics Sajjad Ali1*, Syed Atif Raza2, Humayun Riaz1, Mobasher Ahmad Butt2, Hamid Saeed2, Zikria Saleem2, Tanveer Ahmed Khan1, and Muhammad Ishfaq Ahmad1 1Rashid Latif College of Pharmacy, Lahore, Pakistan. 2University College of Pharmacy, University of the Punjab, Lahore, Pakistan. Authors’ contributions This work was carried out in collaboration between all authors. Author SA designed the study, performed the statistical analysis, wrote the protocol and the first draft of the manuscript. Author MAB was supervisor of the study. Authors HS and ZS were co-supervisors. Authors SAR, HR, TAK and MIA managed analyses of the study. Authors SA and TAK managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/BJPR/2017/33437 Editor(s): (1) Othman Ghribi, Department of Pharmacology, Physiology & Therapeutics, University of North Dakota, USA. Reviewers: (1) Elvira Bormusov, Technion Institute of Technology, Israel. (2) Bidita Khandelwal, Sikkim Manipal Institute of Medical Sciences Sikkim, India. (3) Mario Bernardo-Filho, Universidade do Estado do Rio de Janeiro, Brazil. (4) Mustapha Diaf, Djillali LIABES University, Algeria. Complete Peer review History: http://www.sciencedomain.org/review-history/19311 Received 15th April 2017 Accepted 22th May 2017 Published 2nd June 2017 ABSTRACT Aims: The aim of present study was to evaluate the clinical efficacy of different insulin regimens in non-insulin dependent diabetic patients with respect to their age and gender. Methodology: A prospective cross-sectional study was conducted for comparing different insulin regimens in type II diabetic patients for better glycemic control with respect to age and gender. A total of 234 consenting, known type II diabetic patients, on any insulin regimens, with at least all relevant medical records of preceding three months participated in the study. Patients were segregated into six treatment arms depending upon type of insulin prescribed i.e., insulin pre-mix 70/30, insulin split mix (N & R), long acting insulin analogue, ultra-short acting insulin analogue, insulin pre-mix 70/30 analogue and insulin pre-mix 50/50 analogue, respectively. Moreover, patients from each group were evaluated regarding diabetes knowledge and medication adherence using Michigan Diabetes Research and Training Center’s Revised Diabetes Knowledge test Performa, 23 items and Morisky medication adherence scale, 4 items, respectively. Results: Data analysis showed highly significant association among different insulin regimens with respect to the patient education (p=0.000) level. Significant association was found among different insulin regimens and patient’s occupational status (P=0.013). However, Statistically non-significant associations were observed among different insulin regimens with gender (P=0.070), marital status (P=0.183) and age (P=0.084) respectively. Conclusion: In conclusion, data demonstrated that four treatment groups i.e., long acting insulin analogue, ultra-short acting insulin analogue, insulin premix 70/30 analogue insulin pre-mix 50/50 analogue were more effective than two conventional treatment groups i.e., Insulin pre-mix 70/30 and insulin split mix (N &R) in terms of clinical outcomes in population under study. Furthermore, it was also evident from the data female receiving more insulin than males.
Authors and Affiliations
Sajjad Ali, Syed Atif Raza, Humayun Riaz, Mobasher Ahmad Butt, Hamid Saeed, Zikria Saleem, Tanveer Ahmed Khan, Muhammad Ishfaq Ahmad
Keywords
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- EP ID EP312880
- DOI 10.9734/BJPR/2017/33437
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