Abstract

Aim: Increasing evidence shows that the microenvironment of a tumour plays a significant role in tumour development and progression and this is not only a passive observer. In this study, the immunohistochemical staining pattern of the stromal cells in the tumour microenvironment, which is rarely discussed in the literature, has been demonstrated by considering p53 and HSF1 which are important molecular proteins in the tumorigenesis. Material and Method: Sixty-nine pancreaticoduodenectomy specimens that performed between 2000 and 2012 were re-evaluated in the terms of HSF1/P53 expressions for tumour microenvironment and tumoral cells. The findings were statistically analyzed. Results: Significant difference was observed between tumoural microenvironment and tumoural cells in the terms of HSF1 staining (p < 0.05). For P53, this difference was only observed in pancreatic carcinomas (p < 0.05). Conclusion: Significant staining of two well-known immunomarkers as P53 and HSF1 in stromal cells has further increased the importance of tumour microenvironment in tumorigenesis.

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