A double blind, randomized, controlled trial to study the effect of dexmedetomidine on hemodynamic and recovery responses during tracheal extubation

Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 3, Issue 2

Abstract

Background: Extubation is known to produce significant hemodynamic disturbances. Literature claims that dexmedetomidine, provides excellent cardiovascular stability, no respiratory depression and may be a useful adjunct to facilitate smooth tracheal extubation. Aim: To study the effect of Dexmedetomidine on haemodynamics and recovery response during tracheal extubation. Materials and Methods: sixty persons of American Society of Anesthesiologists grade I II, aged 20 45 years, scheduled for elective general surgery and Obstetrics and Gynecology were studied after randomization into two groups. Group D and C received an intravenous infusion of dexmedetomidine 0.5 µg/kg or placebo respectively, over 10 minutes before anticipated time of end of surgery, in a double blind manner. Anesthesia techniques were standardized. Vitals were recorded while starting of the injection, before extubation and at 3 and 10 minutes after extubation. Quality of extubation was evaluated on a 5 point scale and postoperative sedation on a 6 point scale. Adverse events were recorded. Results: Heart rate, systolic, diastolic, mean arterial pressures were significantly higher in group C (P <0.05). Extubation quality score of majority of patients was 2 in group D and 3 in group C. Sedation score of most patients was 3 in group D and 2 in group C. Bradycardia and hypotension incidences were higher in group D. Hypertension, tachycardia and agitations were more in control group. One patient in group D, two patients in group C had vomiting. Complications were also more in control group. Conclusion: Dexmedetomidine 0.5 µg/kg administered 10 minutes before extubation, stabilizes hemodynamics and facilitates smooth extubation

Authors and Affiliations

Chintala Kishan, Gopal Reddy Narra

Keywords

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